Stevens J C, Eigen H, Wysomierski D
Department of Pediatrics, James Whitcomb Riley Hospital for Children, Indianapolis, Indiana 46223.
Pediatr Pulmonol. 1988;5(2):74-81. doi: 10.1002/ppul.1950050203.
To assess residual damage from meconium aspiration syndrome (MAS), we studied 12 children, ages 6 to 9 years, an average of 7.4 years after injury. Our sample consisted of mildly affected patients, only one having required intubation and mechanical ventilation in the acute phase of illness. In each child we measured FVC, FEV1, PEFR, MMEFR, VisoV, lung volumes by plethysmography, DLCO and calculated FEV1/FVC and RV/TLC. Methacholine bronchial challenge was performed and the PD20 was calculated. These results were compared with those obtained from a group of 12 normal children studied in our laboratory. No significant difference was found for pulmonary function parameters studied, except for VisoV which was greater in MAS patients than normals (P less than 0.02). Given the inherent high degree of variability with VisoV, we were not able to ascribe this isolated finding to be indicative of small airway disease in these asymptomatic patients. We conclude that patients with mild to moderate initial insult from MAS show an absence of pulmonary sequelae when tested at an average of 7.4 years of age.
为评估胎粪吸入综合征（MAS）造成的残余损害，我们研究了12名年龄在6至9岁、受伤后平均7.4年的儿童。我们的样本由轻度受影响的患者组成，只有1名患者在疾病急性期需要插管和机械通气。我们测量了每个儿童的用力肺活量（FVC）、第一秒用力呼气容积（FEV1）、呼气峰值流速（PEFR）、最大呼气中期流速（MMEFR）、比气道传导率（VisoV）、通过体积描记法测得的肺容积、一氧化碳弥散量（DLCO），并计算了FEV1/FVC和残气量/肺总量（RV/TLC）。进行了乙酰甲胆碱支气管激发试验并计算了PD20。将这些结果与在我们实验室研究的一组12名正常儿童的结果进行了比较。在所研究的肺功能参数中未发现显著差异，但MAS患者的VisoV高于正常儿童（P<0.02）。鉴于VisoV固有的高度变异性，我们无法将这一单独发现归因于这些无症状患者的小气道疾病。我们得出结论，平均在7.4岁接受检测时，最初受到轻度至中度MAS损伤的患者未出现肺部后遗症。
