Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu 501-1196, Japan.
Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu 501-1196, Japan.
J Pharmacol Sci. 2020 Jun;143(2):117-121. doi: 10.1016/j.jphs.2020.02.011. Epub 2020 Mar 9.
There are several animal models of glucocorticoid-induced osteoporosis (GIOP), but each requires a long time to evaluate drug effects. Zebrafish scales are classified as dermal bone and potentially represent a convenient animal model of GIOP because they rapidly regenerate following their removal. We clarified that dexamethasone-treated regenerating scales showed malformations, decreased size and circularity. Anti-osteoporosis drugs rescued the scale malformation phenotype eight-days following the removal of scales. Hence, the dexamethasone-induced regenerating scale malformation model may be a useful animal model for discovering drugs to treat GIOP.
有几种糖皮质激素诱导性骨质疏松症（GIOP）的动物模型，但每种模型都需要很长时间来评估药物的效果。斑马鱼鳞片被归类为真皮骨，可能是 GIOP 的一种方便的动物模型，因为它们在去除后会迅速再生。我们阐明了地塞米松处理的再生鳞片表现出畸形、尺寸减小和圆形度降低。在去除鳞片后 8 天，抗骨质疏松药物挽救了鳞片畸形表型。因此，地塞米松诱导的再生鳞片畸形模型可能是一种有用的动物模型，可用于发现治疗 GIOP 的药物。
