先天免疫系统的表观遗传记忆。
The epigenetically-encoded memory of the innate immune system.
机构信息
Committee on Immunology, University of Chicago, Chicago, IL 60637, USA; Medical Scientist Training Program, The University of Chicago, Chicago, IL 60637, USA.
Committee on Immunology, University of Chicago, Chicago, IL 60637, USA; Department of Medicine, Section of Genetic Medicine, University of Chicago, Chicago, IL 60637, USA.
出版信息
Curr Opin Immunol. 2020 Aug;65:7-13. doi: 10.1016/j.coi.2020.02.002. Epub 2020 Mar 25.
Abstract
Stimulation or infection of innate immune cells induces profound epigenetic changes, including the induction of histone modifications and alterations in DNA methylation levels. While some of these changes are rapidly reversible, others appear to be long-lasting, even in mitotic populations, with important functional consequences for the stimulus-experienced cell. Here we discuss the individual contributions of each of the plethora of known epigenetic modifications to the initial transcriptional response to immune activation, their dynamics as cells return to homeostasis, and their contribution to memory of the initial stimulus.
摘要
先天免疫细胞的刺激或感染会诱导深刻的表观遗传变化，包括组蛋白修饰的诱导和 DNA 甲基化水平的改变。虽然其中一些变化是快速可逆的，但其他变化似乎是持久的，即使在有丝分裂群体中也是如此，这对经历刺激的细胞有重要的功能后果。在这里，我们讨论了众多已知表观遗传修饰中的每一种对免疫激活初始转录反应的单独贡献，它们在细胞恢复到体内平衡时的动态变化，以及它们对初始刺激记忆的贡献。
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