p-ATM/CHK2 在鼻腔结外 NK/T 细胞淋巴瘤，鼻型中的异常表达与不良预后相关。

Abnormal expression of p-ATM/CHK2 in nasal extranodal NK/T cell lymphoma, nasal type, is correlated with poor prognosis.

机构信息

Department of Pathology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China.

Department of Pathology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China

出版信息

J Clin Pathol. 2021 Apr;74(4):223-227. doi: 10.1136/jclinpath-2020-206476. Epub 2020 Mar 27.

DOI:10.1136/jclinpath-2020-206476

PMID:32220941

Abstract

AIMS

The aim of this study is to investigate the expression profiles of cell cycle related proteins in nasal extranodal NK/T cell lymphoma, nasal type (ENKTCL).

METHODS

The expression profiles of cell cycle related proteins were assessed with a cell cycle antibody array and validated by immunohistochemistry. Correlations between the expression levels of proteins and clinical outcomes of patients with nasal ENKTCL were evaluated.

RESULTS

The expression of full length ataxia telangiectasia mutated (ATM) in nasal ENKTCL significantly decreased compared with that in nasal benign lymphoid proliferative disease (NBLPD), but the expression levels of p-ATM, CHK2 and RAD51 significantly increased in nasal ENKTCL compared with that in NBLPD. Kaplan-Meier analysis showed that the expression levels of p-ATM and CHK2 in nasal ENKTCL were inversely related to overall survival (p=0.011 and p=0.025, respectively).

CONCLUSION

Abnormalities in the ATM pathway may play a crucial role in the oncogenesis and chemoradiotherapy resistance of nasal ENKTCL.

摘要

目的

本研究旨在探讨鼻型结外 NK/T 细胞淋巴瘤（ENKTCL）中细胞周期相关蛋白的表达谱。

方法

采用细胞周期抗体阵列评估细胞周期相关蛋白的表达谱，并通过免疫组织化学进行验证。评估了鼻型 ENKTCL 患者蛋白表达水平与临床结局之间的相关性。

结果

与鼻良性淋巴组织增生性疾病（NBLPD）相比，鼻型 ENKTCL 中全长共济失调毛细血管扩张突变（ATM）的表达显著降低，但 p-ATM、CHK2 和 RAD51 的表达水平显著升高。Kaplan-Meier 分析显示，鼻型 ENKTCL 中 p-ATM 和 CHK2 的表达水平与总生存期呈负相关（p=0.011 和 p=0.025）。