Klucka Jozef, Kosinova Martina, Zacharowski Kai, De Hert Stefan, Kratochvil Milan, Toukalkova Michaela, Stoudek Roman, Zelinkova Hana, Stourac Petr
From the Department of Paediatric Anaesthesiology and Intensive Care Medicine, University Hospital Brno and Faculty of Medicine, Masaryk University, Jihlavska, Brno, Czech Republic (JK, MKo, MKr, MT, RS, PS), Department of Anaesthesiology, Intensive Care Medicine & Pain Therapy, University Hospital Frankfurt, Frankfurt, Goethe University, Germany (KZ), Department of Anaesthesiology and Peri-operative Medicine, Ghent University Hospital, Ghent University, Ghent, Belgium (SDH) and Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Jihlavska, Brno, Czech Republic (HZ).
Eur J Anaesthesiol. 2020 Jun;37(6):435-442. doi: 10.1097/EJA.0000000000001194.
Rapid sequence induction (RSI) is a standard procedure, which should be implemented in all patients with a risk of aspiration/regurgitation during anaesthesia induction.
The primary aim was to evaluate clinical practice in RSI, both in adult and paediatric populations.
Online survey.
A total of 56 countries.
Members of the European Society of Anaesthesiology.
The aim was to identify and describe the actual clinical practice of RSI related to general anaesthesia.
From the 1921 respondents, 76.5% (n=1469) were qualified anaesthesiologists. When anaesthetising adults, the majority (61.7%, n=1081) of the respondents preoxygenated patients with 100% O2 for 3 min and 65.9% (n=1155) administered opioids during RSI. The Sellick manoeuvre was used by 38.5% (n=675) and was not used by 37.4% (n=656) of respondents. First-line medications for a haemodynamically stable adult patient were propofol (90.6%, n=1571) and suxamethonium (56.0%, n=932). Manual ventilation (inspiratory pressure <12 cmH2O) was used in 35.5% (n=622) of respondents. In the majority of paediatric patients, 3 min of preoxygenation (56.6%, n=817) and opioids (54.9%, n=797) were administered. The Sellick manoeuvre and manual ventilation (inspiratory pressure <12 cmH2O) in children were used by 23.5% (n=340) and 35.9% (n=517) of respondents, respectively. First-line induction drugs for a haemodynamically stable child were propofol (82.8%, n=1153) and rocuronium (54.7%, n=741).
We found significant heterogeneity in the daily clinical practice of RSI. For patient safety, our findings emphasise the need for international RSI guidelines.
ClinicalTrials.gov identifier: NCT03694860.
快速顺序诱导(RSI)是一种标准操作程序,应在所有麻醉诱导期间有误吸/反流风险的患者中实施。
主要目的是评估成人和儿童群体中RSI的临床实践情况。
在线调查。
总共56个国家。
欧洲麻醉学会成员。
目的是识别和描述与全身麻醉相关的RSI实际临床实践情况。
在1921名受访者中,76.5%(n = 1469)为合格麻醉医生。在麻醉成人时,大多数受访者(61.7%,n = 1081)用100%氧气对患者进行3分钟预充氧,65.9%(n = 1155)在RSI期间给予阿片类药物。38.5%(n = 675)的受访者使用了Sellick手法,37.4%(n = 656)的受访者未使用。对于血流动力学稳定的成年患者,一线用药是丙泊酚(90.6%,n = 1571)和琥珀胆碱(56.0%,n = 932)。35.5%(n = 622)的受访者采用手动通气(吸气压力<12 cmH₂O)。在大多数儿科患者中,进行了3分钟预充氧(56.6%,n = 817)并给予阿片类药物(54.9%,n = 797)。分别有23.5%(n = 340)和35.9%(n = 517)的受访者在儿童中使用了Sellick手法和手动通气(吸气压力<12 cmH₂O)。对于血流动力学稳定的儿童,一线诱导药物是丙泊酚(82.8%,n = 1153)和罗库溴铵(54.7%,n = 741)。
我们发现RSI的日常临床实践存在显著异质性。为了患者安全,我们的研究结果强调了制定国际RSI指南的必要性。
ClinicalTrials.gov标识符:NCT03694860。