From the Pediatric Infectious Diseases Department. Hospital 12 de Octubre, Madrid, Spain.
Department of Pediatrics, Hospital of Lithuanian University of Health Sciences Kauno klinikos, Lithuanian University of Health Science, Kaunas, Lithuania.
Pediatr Infect Dis J. 2020 Jun;39(6):e73-e76. doi: 10.1097/INF.0000000000002640.
To analyze host and pathogen factors related to disease severity of community-acquired bone and joint infections in children, a cohort of pediatric patients was prospectively recruited from 13 centers in 7 European countries. A total of 85 children were included, 11 (13%) had a severe infection. Panton-Valentine leukocidin-positive isolates were 17%, and 6% of the isolates were methicillin-resistant Staphylococcus aureus. Multivariate analysis identified Panton-Valentine leukocidin presence (adjusted odds ratio, 12.6; P = 0.01) as the only factor independently associated with severe outcome, regardless of methicillin resistance.
为分析导致儿童社区获得性骨和关节感染严重程度的宿主和病原体因素，我们在欧洲 7 个国家的 13 个中心前瞻性地招募了一组儿科患者。共有 85 名儿童入组，其中 11 名（13%）患有严重感染。检出携带杀白细胞素 Panton-Valentine 的分离株占 17%，耐甲氧西林金黄色葡萄球菌占 6%。多变量分析确定携带杀白细胞素 Panton-Valentine （调整优势比，12.6；P=0.01）是与严重结局相关的唯一独立因素，与耐甲氧西林无关。
