慢性淋巴细胞白血病（CLL）中抗红细胞和血小板自身抗体的发生率及预后意义。
Incidence and prognostic significance of autoantibodies against erythrocytes and platelets in chronic lymphocytic leukemia (CLL).
作者信息
De Rossi G, Granati L, Girelli G, Gandolfo G, Arista M C, Martelli M, Conti L, Marini R, La Tagliata R, Leone R
机构信息
Human Biopathology Dept, University La Sapienza, Rome.
出版信息
Nouv Rev Fr Hematol (1978). 1988;30(5-6):403-6.
Antiglobulin Test (AT), and Dixon Tests (DT) have been studied in 100 patients with CLL. Thirty-five patients were Rai stage 0 and I, 19 patients stage 2, 13 patients stage 3 and 33 patients stage 4. Twelve patients showed a Red Blood Cells Autoantibodies (RBCAb) positivity; a positivity (direct, indirect, or both) of DT was present in 74% of patients. The presence of autoantibodies against erythrocytes and platelets did not influence survival curves, but anemia and thrombocytopenia are risk factors for survival, independently of the presence of an autoimmune disorder. Nine patients RBCAb positive and DT positive showed the worst survival curve, five out of these were anemic and one thrombocytopenic and anemic.
对100例慢性淋巴细胞白血病（CLL）患者进行了抗球蛋白试验（AT）和迪克森试验（DT）。35例患者为Rai 0期和I期，19例为2期，13例为3期，33例为4期。12例患者红细胞自身抗体（RBCAb）呈阳性；74%的患者DT呈阳性（直接阳性、间接阳性或两者均阳性）。抗红细胞和血小板自身抗体的存在不影响生存曲线，但贫血和血小板减少是生存的危险因素，与自身免疫性疾病的存在无关。9例RBCAb阳性且DT阳性的患者生存曲线最差，其中5例贫血，1例血小板减少且贫血。
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