成人结肠平滑肌肉瘤手术治疗的危险因素的汇总分析。
A pooled analysis of risk factors of surgically treated leiomyosarcoma of the colon in adults.
机构信息
Department of Digestive System, Qinghai University Affiliated Hospital, Xining, 810000, Qinghai, China.
Qinghai University, Xining, 810000, Qinghai, China.
出版信息
World J Surg Oncol. 2020 Mar 28;18(1):61. doi: 10.1186/s12957-020-01838-3.
BACKGROUND
This current systematic review aimed to evaluate the role of surgical management and risk factors by pooled cases from all identified patients with colonic leiomyosarcomas.
METHODS
The authors searched the Ovid MEDLINE, Embase, PubMed, and Cochrane databases using the keywords "colonic," "colon," and "leiomyosarcoma." Risk factors of colonic leiomyosarcoma in the pooled cohort were also evaluated.
RESULTS
Between 1923 and 2019, 41 cases of colonic leiomyosarcoma were identified in 22 (53.7%) males and 19 (46.3%) females, with a mean and median age of 58.7 ± 2.2 years and 56.0 years. According to univariate analysis, smaller tumor size < 8 cm was significantly associated with longer progression-free survival (HR = 6.957, 95% CI 1.405-34.442; p = 0.017), and younger age < 60 years was trending toward better overall survival (HR = 2.765, 95% CI 0.924-8.272; p = 0.069).
CONCLUSIONS
Colonic leiomyosarcomas are rare neoplasms with aggressive clinical behaviors. Age < 60 years and tumor size < 8 cm were favorable factors for patients' better survival.
背景
本系统评价旨在通过对所有确诊的结肠平滑肌肉瘤患者的病例进行汇总分析，评估手术治疗的作用和相关风险因素。
方法
作者使用“colonic”、“colon”和“leiomyosarcoma”等关键词，在 Ovid MEDLINE、Embase、PubMed 和 Cochrane 数据库中进行检索。还评估了结肠平滑肌肉瘤的汇总队列中的风险因素。
结果
在 1923 年至 2019 年间，共在 22 名男性（53.7%）和 19 名女性（46.3%）中确诊了 41 例结肠平滑肌肉瘤患者，平均年龄和中位年龄分别为 58.7 ± 2.2 岁和 56.0 岁。单因素分析显示，肿瘤直径较小（< 8cm）与无进展生存期更长显著相关（HR = 6.957，95%CI 1.405-34.442；p = 0.017），年龄较小（< 60 岁）与总生存期更好呈趋势相关（HR = 2.765，95%CI 0.924-8.272；p = 0.069）。
结论
结肠平滑肌肉瘤是一种具有侵袭性临床行为的罕见肿瘤。年龄<60 岁和肿瘤直径<8cm 是患者生存更好的有利因素。
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