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抗酸制剂中和特性的研究。第4部分:威布尔分布函数在二羟基铝碳酸钠中和中的应用。

Studies of neutralizing properties of antacid preparations. Part 4: Application of Weibull distribution function to neutralization of dihydroxyaluminum sodium carbonate.

作者信息

Kokot Z

机构信息

Department of Inorganic and Analytical Chemistry K. Marcinkowki Academy of Medicine, Poznán, Poland.

出版信息

Pharmazie. 1988 Jul;43(7):481-3.

PMID:3222278
Abstract

The rate of neutralization of hydrochlorid acid by dihydroxyaluminum sodium carbonate (DHASC) has been studied by pH-stat method. The neutralization process was examined by monitoring the appearance of aluminum and sodium ions in the reaction medium. The Weibull distribution function was applied to the quantitative interpretation of neutralization rate data. All mathematically meaningful parameters derived from this distribution function were useful for consideration of the mechanism according to which the neutralization of DHASC occurs.

摘要

采用pH计法研究了二羟基铝碳酸钠(DHASC)对盐酸的中和速率。通过监测反应介质中铝离子和钠离子的出现来考察中和过程。将威布尔分布函数应用于中和速率数据的定量解释。从该分布函数导出的所有具有数学意义的参数都有助于考虑DHASC发生中和的机制。

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