Studies of neutralizing properties of antacid preparations. Part 4: Application of Weibull distribution function to neutralization of dihydroxyaluminum sodium carbonate.

The rate of neutralization of hydrochlorid acid by dihydroxyaluminum sodium carbonate (DHASC) has been studied by pH-stat method. The neutralization process was examined by monitoring the appearance of aluminum and sodium ions in the reaction medium. The Weibull distribution function was applied to the quantitative interpretation of neutralization rate data. All mathematically meaningful parameters derived from this distribution function were useful for consideration of the mechanism according to which the neutralization of DHASC occurs.