Sealy Center on Aging, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX, 77555, USA.
Centro Nacional de Enfermedades Reumáticas, Division of Rheumatology, Hospital Universitario, Universidad Central de Venezuela, Caracas, Venezuela.
Qual Life Res. 2020 Aug;29(8):2129-2136. doi: 10.1007/s11136-020-02485-7. Epub 2020 Mar 28.
INTRODUCTION/OBJECTIVE: To examine the effect of depressive symptoms on health-related quality of life (HR-QoL) in Venezuelan patients with rheumatoid arthritis (RA).
HR-QoL was assessed in a cross-sectional, single-center study of 212 consecutive Venezuelan patients with RA (1987 American College of Rheumatology criteria) using the Medical Outcomes Study Short Form (SF-36), which includes a Physical Composite Scale (PCS) and a Mental Composite Scale (MCS); depressive symptoms were assessed using the Center for Epidemiologic Studies Depression Scale. Covariates included socio-demographics, comorbidities, disease characteristics, body mass index, and disability. Unadjusted and multivariable linear regression analysis were used to determine the effect of depressive symptoms on HR-QoL.
Mean age was 50.2 years and 89.6% were female. Twenty-five percent of patients had depressive symptoms. In the multivariable regression analysis, the presence of depressive symptoms changed the mental SF-36 scores by - 4.81 (p = 0.0052) and the physical SF-36 scores by - 3.33 (p = 0.0527). Other factors significantly associated with scores on the PCS of the SF-36 were functional class, disability and job loss due to RA.
The presence of depressive symptoms negatively affected the HR-QoL in our patients, with a predominant effect on the MCS of the SF-36. The PCS of the SF-36 was mainly affected by those symptoms related to the functional impairment and inflammatory activity of the disease. The routine assessment and early treatment of depressive symptoms, targeting mental and mood manifestations, may improve the HR-QoL and thus contribute to healthier outcomes in Venezuelan RA patients.
介绍/目的：研究委内瑞拉类风湿关节炎（RA）患者抑郁症状对健康相关生活质量（HR-QoL）的影响。
采用美国风湿病学会（ACR）1987 年标准确诊的 212 例委内瑞拉 RA 连续患者进行横断面、单中心研究，使用健康调查简表 36 项（SF-36）评估 HR-QoL，包括身体综合评分（PCS）和精神综合评分（MCS）；使用流行病学研究中心抑郁量表评估抑郁症状。协变量包括社会人口统计学、合并症、疾病特征、体重指数和残疾。采用未调整和多变量线性回归分析确定抑郁症状对 HR-QoL 的影响。
患者平均年龄为 50.2 岁，89.6%为女性。25%的患者有抑郁症状。在多变量回归分析中，抑郁症状的存在使精神 SF-36 评分降低了 4.81（p=0.0052），身体 SF-36 评分降低了 3.33（p=0.0527）。与 SF-36 PCS 评分显著相关的其他因素包括功能分级、残疾和因 RA 而失业。
抑郁症状的存在对我们患者的 HR-QoL 产生负面影响，对 SF-36 的 MCS 影响更为明显。SF-36 的 PCS 主要受与疾病功能障碍和炎症活动相关的症状影响。常规评估和早期治疗抑郁症状，针对精神和情绪表现，可能会提高 HR-QoL，从而改善委内瑞拉 RA 患者的健康结果。
