Department of Spine Surgery, Honghui Hospital Affiliated to Xi'an Jiaotong University, Xi'an, China.
Department of pathology, Johns Hopkins University, Baltimore, Maryland, United States.
Curr Stem Cell Res Ther. 2020;15(7):607-613. doi: 10.2174/1574888X15666200330143958.
Gastric cancer (GC) is the fourth-most common cancer in the world, with an estimated 1.034 million new cases in 2015, and the third-highest cause of cancer deaths, estimated at 785,558, in 2014. Early diagnosis and treatment greatly affect the survival rate in patients with GC: the 5-year survival rate of early GC reaches 90%-95%, while the mortality rate significantly increases if GC develops to the late stage. Recently, studies for the role of RhoA in the diseases have become a hot topic, especially in the development of tumors. A study found that RhoA can regulate actin polymerization, cell adhesion, motor-myosin, cell transformation, and the ability to participate in the activities of cell movement, proliferation, migration, which are closely related to the invasion and metastasis of tumor cells. However, the specific role of RhoA in tumor cells remains to be studied. Therefore, our current study aimed to briefly review the role of RhoA in GC, especially for its associated signaling pathways involved in the GC progression.
胃癌（GC）是世界上第四大常见癌症，2015 年估计有 103.4 万新发病例，2014 年癌症死亡人数排名第三，估计有 78.5588 万人。早期诊断和治疗极大地影响 GC 患者的生存率：早期 GC 的 5 年生存率达到 90%-95%，而如果 GC 发展到晚期，死亡率则显著增加。最近，研究 RhoA 在疾病中的作用已成为一个热门话题，尤其是在肿瘤的发展中。一项研究发现，RhoA 可以调节肌动蛋白聚合、细胞黏附、肌球蛋白马达、细胞转化以及参与细胞运动、增殖、迁移的能力，这些都与肿瘤细胞的侵袭和转移密切相关。然而，RhoA 在肿瘤细胞中的具体作用仍有待研究。因此，我们目前的研究旨在简要综述 RhoA 在 GC 中的作用，特别是其与 GC 进展相关的信号通路。
