Department of Biochemistry, Gazi University, Faculty of Medicine, Ankara, Turkey.
Department of Biochemistry, Gazi University, Faculty of Medicine, Ankara, Turkey.
J Clin Neurosci. 2020 May;75:188-194. doi: 10.1016/j.jocn.2019.12.026. Epub 2020 Mar 27.
Alzheimer's Disease (AD) is the most common form of dementia seen in advanced age. It is characterized by progressive deterioration in cognitive functions. The prevalence of Alzheimer's disease increasing day by day due to the increase in the share of the elderly population in the general population due to developing health and living conditions, is limited and early diagnosis and effective treatment possibilities are very limited. From this point of view, a specific biomarker for AD is very important. As a new oxidative stress biomarker, the levels of thiol-disulfide balance, ischemia-modified albumin and seroloplazminin were evaluated. The aim of this study was to determine the serum levels of oxidative stress biomarkers in the early stages of the disease and to compare these oxidative stress markers with patients with mild cognitive impairment as a precursor form of Alzheimer's disease and to determine whether these markers develop at an earlier stage.
30 volunteers with early stage AD according to NINCDS-ARDRA criteria, 19 volunteers with Midl Cognitive İmpairment according to PCA criteria and 30 volunteers with defined criteria were selected from the subjects aged between 55 and 88 who applied to Gazi University Health Research. Statistical analysis of the data showed that there was a significant difference between the endgroups and biomarkers for the early diagnosis of Alzheimer's disease, but this complicated matter has to be investigated in more comprehensive and detailed studie.
In the present study, we investigated oxidative stress parameters, thiol-disulphide balance, ischemia modified abumin and seruloplasmin in parallel with the impairment in cognitive dysfunction from control group to Mild Cognitive Impairment (MCD) and AD group by using a newly-developed method.
This is the first study in literature comparing Early Stages Alzheimer Disease (ESAD), MCD and healthy volunteer groups. Our study has revealed that these newly developed tests may be candidates as oxidative stress biomarkers in pathgenesis of AD. However it was concluded that more comprehensive and detailed studies are required to enlighten this issue.
阿尔茨海默病（AD）是老年人群中最常见的痴呆症形式。其特征是认知功能逐渐恶化。由于健康和生活条件的改善，老年人口在总人口中的比例增加，导致阿尔茨海默病的患病率日益增加，但早期诊断和有效治疗的可能性非常有限。从这个角度来看，针对 AD 的特定生物标志物非常重要。作为一种新的氧化应激生物标志物，评估了硫醇-二硫键平衡、缺血修饰白蛋白和血清铜蓝蛋白的水平。本研究旨在确定疾病早期阶段的氧化应激生物标志物水平，并将这些氧化应激标志物与轻度认知障碍患者（AD 的前驱形式）进行比较，以确定这些标志物是否在更早的阶段出现。
根据 NINCDS-ARDRA 标准选择 30 名早期 AD 志愿者、根据 PCA 标准选择 19 名轻度认知障碍志愿者，以及从年龄在 55 至 88 岁之间申请加济大学健康研究的受试者中选择 30 名符合标准的志愿者。数据分析表明，各组之间存在显著差异，并且这些生物标志物可用于早期诊断 AD，但这一复杂问题需要在更全面和详细的研究中进行探讨。
在本研究中，我们通过使用新开发的方法平行研究了从对照组到轻度认知障碍（MCI）和 AD 组的氧化应激参数、硫醇-二硫键平衡、缺血修饰白蛋白和血清铜蓝蛋白，与认知功能障碍的损害。
这是文献中首次比较早期阿尔茨海默病（ESAD）、MCI 和健康志愿者组的研究。我们的研究表明，这些新开发的测试可能是 AD 发病机制中氧化应激生物标志物的候选者。然而，需要进行更全面和详细的研究来阐明这一问题。
