Division of Geriatric Medicine, Department of Internal Medicine, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Department of Clinical Biochemistry, Yıldırım Beyazit University Faculty of Medicine, Ankara, Turkey.
Geriatr Gerontol Int. 2021 Jul;21(7):584-589. doi: 10.1111/ggi.14199. Epub 2021 Jun 2.
Sarcopenia is characterized by progressive and generalized loss of skeletal muscle mass and strength. Chronic inflammatory conditions and increased oxidative stress are in the pathogenesis of sarcopenia. Our aim was to evaluate the relationship between sarcopenia and thiol-disulfide homeostasis and ischemia-modified albumin levels as an oxidative stress marker.
Patients aged ≥65 years were recruited in this study. Sarcopenia was diagnosed according to the European Working Group on Sarcopenia in Older People criterion. Total thiol, native thiol, disulfide and ischemia-modified albumin levels were measures according to clinical and laboratory features. Patients were divided into two groups according to their sarcopenia presence; thiol-disulfide homeostasis and ischemia-modified albumin levels were evaluated between these groups.
Overall, 94 patients were analyzed. The mean age was 75.0 ± 6.71 years. A total of 39% of the patients were diagnosed as probable sarcopenia, 3.2% had sarcopenia, 6.4% had severe sarcopenia and 51.1% were diagnosed as normal. The levels of native thiol, total thiol, disulfide level and disulfide-native thiol, native thiol-total thiol and disulfide-total thiol ratios were similar in patients with sarcopenia when compared with the control group. In addition, there were no differences between albumin and ischemia-modified albumin levels. In univariate regression analysis, handgrip strength was found to be an independent predictor of native thiol and total thiol, and disulfide levels.
This is the first study in the literature that evaluates the thiol-disulfide homeostasis and ischemia-modified albumin levels in sarcopenic older patients. Long-term studies are warranted to confirm the relationship between oxidative stress markers and sarcopenia. Geriatr Gerontol Int 2021; 21: 584-589.
肌少症的特征是骨骼肌质量和力量进行性和广泛性丧失。慢性炎症状态和氧化应激增加是肌少症发病机制的一部分。我们的目的是评估肌少症与硫醇-二硫键平衡和缺血修饰白蛋白（氧化应激标志物）水平之间的关系。
本研究纳入了年龄≥65 岁的患者。根据欧洲老年人肌少症工作组的标准诊断肌少症。根据临床和实验室特征测量总巯基、天然巯基、二硫键和缺血修饰白蛋白水平。根据患者是否存在肌少症将其分为两组，评估两组间硫醇-二硫键平衡和缺血修饰白蛋白水平。
共分析了 94 例患者，平均年龄为 75.0±6.71 岁。39%的患者被诊断为可能的肌少症，3.2%的患者患有肌少症，6.4%的患者患有严重的肌少症，51.1%的患者被诊断为正常。与对照组相比，肌少症患者的天然巯基、总巯基、二硫键水平以及二硫键/天然巯基、天然巯基/总巯基和二硫键/总巯基比值无差异。此外，白蛋白和缺血修饰白蛋白水平也无差异。在单因素回归分析中，握力被发现是天然巯基和总巯基以及二硫键水平的独立预测因子。
这是文献中首次评估老年肌少症患者的硫醇-二硫键平衡和缺血修饰白蛋白水平的研究。需要进行长期研究来证实氧化应激标志物与肌少症之间的关系。老年医学与老年健康杂志 2021;21:584-589。
