Department of Psychology, Center for Lifespan Changes in Brain and Cognition, University of Oslo, Oslo, Norway; Research Department, Sunnaas Rehabilitation Hospital, Nesoddtangen, Norway.
Department of Psychology, Center for Lifespan Changes in Brain and Cognition, University of Oslo, Oslo, Norway; Department of radiology and nuclear medicine, Oslo University Hospital, Oslo, Norway.
Neurobiol Aging. 2020 Jul;91:112-124. doi: 10.1016/j.neurobiolaging.2019.10.005. Epub 2019 Oct 14.
Higher levels of body fat have shown adverse effects on multiple aspects of health, including cognitive and neuroanatomical changes. We tested the relationships of body fat levels and cholesterol to longitudinal age trajectories of subcortical gray matter volume (SCV), hippocampal volume (HCV), and episodic memory. Body fat was indexed by a concerted factor of BMI, visceral adipose tissue, percentage body fat, and total fat mass and was included in the analyses as a cross-sectional measure. We hypothesized that higher level of body fat would be related to steeper age trajectories of SCV, HCV, and memory. The sample consisted of 581 participants (20-83 years) with 942 magnetic resonance imaging and 945 memory examinations. Using generalized additive mixed models, a negative effect of body fat was found on SCV, HCV, and memory. Age and body fat interacted in their association with brain volume change. The results suggest that among cognitively healthy adults, there is a negative effect of higher body fat on SCV, HCV, and memory decline, an effect that increased with age for the neuroanatomical volumes.
体脂肪水平升高对健康的多个方面都有不利影响，包括认知和神经解剖结构的变化。我们检验了体脂肪水平和胆固醇与皮质下灰质体积（SCV）、海马体积（HCV）和情景记忆的纵向年龄轨迹之间的关系。体脂肪通过 BMI、内脏脂肪组织、体脂肪百分比和总脂肪量的综合因子来表示，并作为横断面测量指标纳入分析。我们假设较高的体脂肪水平与 SCV、HCV 和记忆的年龄轨迹更陡峭有关。该样本包括 581 名参与者（20-83 岁），有 942 次磁共振成像和 945 次记忆检查。使用广义加性混合模型，发现体脂肪对 SCV、HCV 和记忆有负面影响。年龄和体脂肪在与大脑体积变化的关联中存在相互作用。结果表明，在认知健康的成年人中，较高的体脂肪对 SCV、HCV 和记忆下降有负面影响，这种影响随着年龄的增长而增加，对神经解剖结构体积的影响也随之增加。
