薯蓣皂素 A-G，一种来自徐长卿的新生物碱及其抗 TMV 活性。
Stemtuberolines A-G, new alkaloids from Stemona tuberosa and their anti-TMV activity.
机构信息
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, PR China; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, PR China.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China; School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China.
出版信息
Fitoterapia. 2020 Jun;143:104572. doi: 10.1016/j.fitote.2020.104572. Epub 2020 Mar 26.
Three new tuberostemoamide-type alkaloids, stemtuberolines A-C (1-3), four new stenine-type alkaloids, stemtuberolines D-G (4-7), together with five known Stemona alkaloids (8-12), were isolated from the roots of Stemona tuberosa. Their structures were elucidated on the basis of comprehensive spectroscopic data analysis. Stemtuberoline C (3) exhibited significant anti-TMV activity with an inhibition rate of 60.48% at the concentration of 50 μg/mL, while that of ningnamycin, the positive control, was 52.89%.
从直立百部根中分离得到了三个新的百部螺胺型生物碱，即 Stemtuberolines A-C（1-3），四个新的石蒜碱型生物碱，即 Stemtuberolines D-G（4-7），以及五个已知的百部生物碱（8-12）。基于综合光谱数据分析，鉴定了它们的结构。Stemtuberoline C（3）在 50μg/mL 浓度下表现出显著的抗 TMV 活性，抑制率为 60.48%，阳性对照宁南霉素的抑制率为 52.89%。
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