从无梗乌头中分离得到的 7 个新的邻氨基苯甲酰胺衍生物。
Seven new anthranilamide derivatives from Aconitum apetalum.
机构信息
The Xinjiang Technical Institute of Physics & Chemistry, Chinese Academy of Sciences, Urumqi 830011, PR China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China; University of Chinese Academy of Sciences, Yuquan Road 19, Beijing 100049, PR China; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, PR China; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, PR China.
The Institute of Biotechnology and Germplasm Resources, Yunnan Academy of Agricultural Sciences, Kunming 650204, PR China.
出版信息
Fitoterapia. 2018 Jul;128:73-78. doi: 10.1016/j.fitote.2018.05.008. Epub 2018 May 14.
Seven new anthranilamide derivatives, acoapetalines A-G (1-7), including one new naturally occurring compound (7), together with six known ones (8-13) were isolated from the whole plants of Aconitum apetalum. Their structures were established on the basis of extensive spectroscopic analyses (IR, UV, HRESIMS, 1D and 2D NMR). All compounds were evaluated for their anti-tobacco mosaic virus (anti-TMV) activities. The results showed that compound 10 exhibited significant anti-TMV activity with an inhibition rate of 67.57% (100 μg/mL), which was higher than that of ningnamycin (52.89%).
从无叶乌头全草中分离得到了 7 个新的邻苯二甲酰亚胺衍生物，accoapetalines A-G（1-7），包括一个新的天然产物（7），以及 6 个已知化合物（8-13）。根据广泛的光谱分析（IR、UV、HRESIMS、1D 和 2D NMR）确定了它们的结构。所有化合物均进行了抗烟草花叶病毒（anti-TMV）活性评价。结果表明，化合物 10 具有显著的抗 TMV 活性，抑制率为 67.57%（100μg/mL），高于宁南霉素（52.89%）。
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