Berry C L
Department of Morbid Anatomy, London Hospital Medical College, United Kingdom.
Regul Toxicol Pharmacol. 1988 Dec;8(4):385-8. doi: 10.1016/0273-2300(88)90036-0.
The term "no-observable-effect level" is preferable to "no-effect level" to indicate the impossibility of demonstrating no effect. The term "no-adverse-effect level" is sometimes used, indicating that not all changes are of toxicological relevance. The size of the safety factor can be justified scientifically only when good toxicokinetic and metabolic information exists. Actually, extrapolation and risk evaluation can be carried out in a proper way only when the mechanism underlying a particular effect is known. The use of recovery groups in long-term studies is recommended.
术语“无可见效应水平”比“无效应水平”更可取，以表明证明无效应是不可能的。有时使用术语“无有害效应水平”，这表明并非所有变化都具有毒理学相关性。只有当有良好的毒代动力学和代谢信息时，安全系数的大小才能从科学上得到证明。实际上，只有当特定效应的潜在机制已知时，才能以适当的方式进行外推和风险评估。建议在长期研究中使用恢复组。
