Layton D W, Mallon B J, Rosenblatt D H, Small M J
Regul Toxicol Pharmacol. 1987 Mar;7(1):96-112. doi: 10.1016/0273-2300(87)90050-x.
The lack of human toxicological data for most chemical compounds makes it difficult to quickly assess health risks associated with exposure to contaminants at hazardous waste sites. It would therefore be advantageous to have a technique for estimating acceptable daily intakes (ADIs) of potentially toxic substances based on more widely available animal toxicity data. This article focuses on the use of LD50 data to derive provisional ADIs, and it suggests multiplying oral LD50 values (expressed in mg/kg of body wt) by a factor in the range of 5 X 10(-6) to 1 X 10(-5) day-1 to convert them to such ADIs. It is emphasized that these interim ADI values are no substitute for toxicity testing, but that such testing would most likely result in higher ADI estimates.
大多数化合物缺乏人体毒理学数据，这使得难以快速评估与接触危险废物场地污染物相关的健康风险。因此，拥有一种基于更广泛可得的动物毒性数据来估算潜在有毒物质每日允许摄入量（ADI）的技术将是有益的。本文重点介绍使用半数致死剂量（LD50）数据来推导临时ADI，并建议将口服LD50值（以mg/kg体重表示）乘以5×10⁻⁶至1×10⁻⁵天⁻¹范围内的系数，以将其转换为这类ADI。需要强调的是，这些临时ADI值不能替代毒性测试，但这类测试很可能会得出更高的ADI估算值。
