Ikeda M
Department of Environmental Health, Tohoku University School of Medicine, Sendai, Japan.
Regul Toxicol Pharmacol. 1988 Dec;8(4):414-21. doi: 10.1016/0273-2300(88)90040-2.
In order to evaluate the possible interactive effects of simultaneous exposure to more than one chemical, leading toxicological journals over the period 1981-1987 were reviewed for articles on combined exposure. Additive effects or less or no interaction were reported in most cases. More than additive effects were reported in 20 out of 104 studies (excluding alcohol), but this conclusion was sometimes not supported by the data. Examples of studies on changes in metabolisms caused by multiple exposure to solvents are given. Metabolic interaction may take place if the chemicals share a common step in their metabolism. Assumption of additive effects in the case of chemicals that share similar action in toxicity can be considered safe enough.
为了评估同时接触多种化学物质可能产生的交互作用，我们查阅了1981年至1987年间主要毒理学杂志上有关联合暴露的文章。大多数情况下报告的是相加作用，或作用较小或无交互作用。在104项研究（不包括酒精）中有20项报告了超相加作用，但这一结论有时得不到数据支持。文中给出了关于多种溶剂联合暴露引起代谢变化的研究实例。如果化学物质在代谢过程中有共同步骤，可能会发生代谢交互作用。对于在毒性方面有相似作用的化学物质，假设其具有相加作用可被认为足够安全。
