Marchewka Zofia, Grzebinoga Agata
Pracownia Markerów Nefrotoksyczności Srodowiskowej, Katedra i Zakład Toksykologii Akademii Medycznej im. Piastów Slaskich we Wrocławiu.
Postepy Hig Med Dosw (Online). 2009 Dec 7;63:592-7.
Although diabetes mellitus, a metabolic disease, does not fall into the group of diseases induced by toxic substances or environmental pollution, there is much evidence that some chemicals have considerable importance in its development. Exposure to substances with potential renal toxicity is especially dangerous for diabetics because it accelerates and intensifies diabetic nephropathy. This paper discusses the relationship between the xenobiotics and the development of diabetes mellitus and diabetic nephropathy with particular emphasis on those substances that causes the greatest damage to the kidneys. These are cadmium, iron, lead, arsenic, polychlorinated organic compounds, nitrogen compounds, and contrast agents. In addition, the mechanisms of diabetes mellitus induction or kidney damage by these xenobiotics are described.
尽管糖尿病作为一种代谢性疾病，并不属于由有毒物质或环境污染诱发的疾病范畴，但有大量证据表明某些化学物质在其发病过程中具有相当重要的作用。接触具有潜在肾毒性的物质对糖尿病患者尤其危险，因为这会加速并加重糖尿病肾病。本文讨论了外源性物质与糖尿病及糖尿病肾病发病之间的关系，特别强调了那些对肾脏造成最大损害的物质。这些物质包括镉、铁、铅、砷、多氯有机化合物、氮化合物和造影剂。此外，还描述了这些外源性物质诱发糖尿病或导致肾脏损伤的机制。
