Peterson M E, Aucoin D P, Davis C A, Graves T K
Department of Medicine, Animal Medical Center, New York, New York.
Res Vet Sci. 1988 Jul;45(1):1-3.
The oral and intravenous disposition of the anti-thyroid drug propylthiouracil (PTU) was determined in six clinically healthy cats and four cats with naturally occurring hyperthyroidism. Compared with the normal cats, the mean plasma elimination half-life of PTU was significantly (P less than 0.001) shorter in the hyperthyroid cats (77.5 +/- 5.8 minutes compared with 125.5 +/- 3.7 minutes) and the total body clearance of PTU was significantly (P less than 0.05) more rapid in the cats with hyperthyroidism (5.1 +/- 0.8 ml kg-1 min-1 compared with 2.7 +/- 0.2 ml kg-1 min-1). Following oral administration, both the bioavailability (59.7 +/- 4.9 per cent compared with 73.3 +/- 3.7 per cent) and peak plasma concentrations (14.5 +/- 1.6 micrograms ml-1 compared with 18.9 +/- 0.9 micrograms ml-1) of PTU were significantly (P less than 0.05) lower in the hyperthyroid cats than in the control cats. No difference was noted, however, between the apparent volume of distribution for PTU in the two groups of cats. Overall, results of this study indicate that the oral bioavailability of PTU is decreased and PTU disposition is accelerated in cats with hyperthyroidism.
在6只临床健康的猫和4只自然发生甲状腺功能亢进的猫中，测定了抗甲状腺药物丙硫氧嘧啶（PTU）的口服和静脉处置情况。与正常猫相比，甲状腺功能亢进猫的PTU平均血浆消除半衰期显著缩短（P<0.001）（分别为77.5±5.8分钟和125.5±3.7分钟），且甲状腺功能亢进猫的PTU全身清除率显著加快（P<0.05）（分别为5.1±0.8 ml·kg-1·min-1和2.7±0.2 ml·kg-1·min-1）。口服给药后，甲状腺功能亢进猫的PTU生物利用度（分别为59.7±4.9%和73.3±3.7%）和血浆峰值浓度（分别为14.5±1.6 μg·ml-1和18.9±0.9 μg·ml-1）均显著低于对照猫（P<0.05）。然而，两组猫中PTU的表观分布容积没有差异。总体而言，本研究结果表明，甲状腺功能亢进猫的PTU口服生物利用度降低，PTU处置加速。
