Reusch C E, Tomsa K
Clinic for Small Animal Internal Medicine, Faculty of Veterinary Medicine, University of Zurich, Switzerland.
J Am Vet Med Assoc. 1999 Nov 1;215(9):1297-300.
To determine the effect of hyperthyroidism on serum fructosamine concentration in cats.
Cohort study.
22 cats with overt hyperthyroidism.
Hyperthyroidism was diagnosed on the basis of clinical signs, detection of a palpable thyroid gland, and high total serum thyroxine (T4) concentrations. Hyperthyroid cats with abnormal serum albumin, total protein, and glucose concentrations were excluded from the study. Samples for determination of serum fructosamine concentration were obtained prior to initiating treatment. Results were compared with fructosamine concentrations in healthy cats, cats in which diabetes had recently been diagnosed, and cats with hypoproteinemia. In 6 cats, follow-up measurements were obtained 2 and 6 weeks after initiating treatment with carbimazole.
Serum fructosamine concentrations ranged from 154 to 267 mumol/L (median, 198 mumol/L) and were significantly lower than values in healthy cats. Eleven (50%) of the hyperthyroid cats had serum fructosamine concentrations less than the reference range. Serum fructosamine concentrations in hyperthyroid, normoproteinemic cats did not differ from values in hypoproteinemic cats. During treatment, an increase in serum fructosamine concentration was detected.
In hyperthyroid cats, concentration of serum fructosamine may be low because of accelerated protein turnover, independent of blood glucose concentration. Serum fructosamine concentrations should not be evaluated in cats with overt hyperthyroidism and diabetes mellitus. Additionally, concentration of serum fructosamine in hyperthyroid cats should not be used to differentiate between diabetes mellitus and transitory stress-related hyperglycemia.
确定甲状腺功能亢进对猫血清果糖胺浓度的影响。
队列研究。
22只明显甲状腺功能亢进的猫。
根据临床症状、可触及甲状腺的检测以及血清总甲状腺素（T4）浓度升高来诊断甲状腺功能亢进。血清白蛋白、总蛋白和葡萄糖浓度异常的甲状腺功能亢进猫被排除在研究之外。在开始治疗前采集用于测定血清果糖胺浓度的样本。将结果与健康猫、近期诊断为糖尿病的猫以及低蛋白血症猫的果糖胺浓度进行比较。对6只猫在开始用卡比马唑治疗后2周和6周进行随访测量。
血清果糖胺浓度范围为154至267μmol/L（中位数为198μmol/L），显著低于健康猫的值。11只（50%）甲状腺功能亢进猫的血清果糖胺浓度低于参考范围。甲状腺功能亢进、正常蛋白血症猫的血清果糖胺浓度与低蛋白血症猫的值无差异。在治疗期间，检测到血清果糖胺浓度升高。
在甲状腺功能亢进的猫中，由于蛋白质周转加速，血清果糖胺浓度可能较低，与血糖浓度无关。对于明显甲状腺功能亢进和糖尿病的猫，不应评估血清果糖胺浓度。此外，甲状腺功能亢进猫的血清果糖胺浓度不应用于区分糖尿病和短暂应激相关的高血糖症。
