Larsen H J, Overnes G, Moksnes K
Norwegian College of Veterinary Medicine, Department of Microbiology and Immunology, Oslo.
Res Vet Sci. 1988 Jul;45(1):11-5.
The effect of selenium (Se) on sheep lymphocyte response to mitogens was studied. In an indoor experiment lambs were fed a basal diet containing 0.13 mg Se kg-1, and supplemented with, respectively, 0.1 or 0.5 mg Se kg-1, either as sodium selenite or as selenomethionine. Enhancement of the proliferative response of lymphocytes to phytohaemagglutinin (PHA), pokeweed mitogen (PWM) and concanavalin A was found in lambs following selenium supplementation at the lower levels. The highest dietary selenium content, however, induced decreased mitogen response. Transient increases in lymphocyte response to PHA and PWM by ewes supplemented with selenium was demonstrated in one field study and a combined effect of selenium and vitamin E was seen in another. There was no stimulatory effect on the mitogen response of lymphocytes from sheep supplemented with dietary vitamin E alone.
研究了硒（Se）对绵羊淋巴细胞对有丝分裂原反应的影响。在一项室内实验中，给羔羊喂食含0.13毫克硒/千克的基础日粮，并分别添加0.1或0.5毫克硒/千克，添加形式为亚硒酸钠或硒代蛋氨酸。在较低水平补充硒后，羔羊淋巴细胞对植物血凝素（PHA）、商陆有丝分裂原（PWM）和刀豆球蛋白A的增殖反应增强。然而，日粮中最高的硒含量导致有丝分裂原反应降低。在一项田间研究中，证明了补充硒的母羊对PHA和PWM的淋巴细胞反应有短暂增加，在另一项研究中则观察到硒和维生素E的联合作用。单独给绵羊补充日粮维生素E对淋巴细胞的有丝分裂原反应没有刺激作用。
