Arnesen E, Halvorsen S, Skjorten F
Scand J Urol Nephrol. 1977;11(1):93-6. doi: 10.3109/00365597709179700.
A case of malacoplakia in a transplanted patient is reported. Several months after the operation typical lesions with numerous Michaelis-Gutmann bodies were found by biopsies from the urinary bladder and the renal transplant, the latter being ultimately destroyed by the process. Recurrent urinary infections with Escherichia coli might have contributed to the development of the process in combination with an altered macrophage function owing to the immunosuppressive regimen, which was considered mainly responsible for the progressive course of an otherwise benign inflammatory reaction. If malacoplakia occurs in a renal transplant and the renal function deteriorates despite adequate antibiotic therapy, transplantectomy should not be delayed.
本文报告了一例移植患者发生软斑病的病例。术后数月，通过膀胱活检和肾移植活检发现了典型病变，其中有大量迈克尔is -古特曼小体，后者最终被该病变过程破坏。由于免疫抑制方案导致巨噬细胞功能改变，复发性大肠杆菌尿路感染可能促使了该病变过程的发展，免疫抑制方案被认为是原本良性炎症反应呈进行性病程的主要原因。如果肾移植中发生软斑病，且尽管进行了充分的抗生素治疗肾功能仍恶化，则不应延迟进行移植肾切除术。
