Hovgaard D, Skinhøj P, Bangsborg J, Bruun B, Mørk Hansen M, Nissen N I
Department of Hematology, Finsen Institute, Rigshospitalet, Copenhagen, Denmark.
Scand J Infect Dis. 1988;20(5):495-501. doi: 10.3109/00365548809032497.
171 episodes of bacteremia and candidemia in 142 patients were recorded during the period 1981-1985 in patients with hematological malignancies. Overall mortality, within 1 week of onset of bacteremia, was 20%. Increased mortality was found in patients with poor disease-prognosis (39%), with granulocytopenia for more than 6 days (30%), and in those developing hypotension (49%). Compared to a similar previous study from 1970-1974, the incidence of bacteremia remained unchanged, but the mortality had decreased by 50%. This result could not be explained by changes in microbial spectrum, in patient groups, or in the initial antibiotic regimen used. An improved general condition of these patients due to better supportive treatment may be the single most important factor in improving the outcome of septicemia.
1981年至1985年期间，对142例血液系统恶性肿瘤患者记录了171次菌血症和念珠菌血症发作。菌血症发作1周内的总死亡率为20%。疾病预后差的患者（39%）、粒细胞减少超过6天的患者（30%）以及出现低血压的患者（49%）死亡率增加。与1970年至1974年之前的一项类似研究相比，菌血症的发病率保持不变，但死亡率下降了50%。这一结果无法用微生物谱、患者群体或所用初始抗生素方案的变化来解释。由于更好的支持治疗，这些患者总体状况的改善可能是改善败血症预后的最重要单一因素。
