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拓展人类巨细胞病毒 pp71 蛋白的已知功能谱。

Expanding the Known Functional Repertoire of the Human Cytomegalovirus pp71 Protein.

机构信息

McArdle Laboratory for Cancer Research, Institute for Molecular Virology, University of Wisconsin - Madison, Madison, WI, United States.

出版信息

Front Cell Infect Microbiol. 2020 Mar 12;10:95. doi: 10.3389/fcimb.2020.00095. eCollection 2020.

DOI:10.3389/fcimb.2020.00095
PMID:32226778
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7080695/
Abstract

The human cytomegalovirus pp71 protein is packaged within the tegument of infectious virions and performs multiple functions in host cells to prime them for productive, lytic replication. Here we review the known and hypothesized functions of pp71 in regulating proteolysis, infection outcome (lytic or latent), histone deposition, transcription, translation, immune evasion, cell cycle progression, and pathogenesis. We also highlight recent advances in CMV-based vaccine candidates informed by an improved understanding of pp71 function.

摘要

人巨细胞病毒 pp71 蛋白包装在感染性病毒粒子的被膜中，并在宿主细胞中发挥多种功能，为其进行有效的裂解性复制做好准备。本文综述了 pp71 在调节蛋白水解、感染结果（裂解或潜伏）、组蛋白沉积、转录、翻译、免疫逃逸、细胞周期进程和发病机制中的已知和假设功能。我们还强调了基于 CMV 的疫苗候选物的最新进展，这些进展得益于对 pp71 功能的更好理解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/032f/7080695/a27734228e81/fcimb-10-00095-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/032f/7080695/77cd5ed9ce82/fcimb-10-00095-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/032f/7080695/c5f53f0285fc/fcimb-10-00095-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/032f/7080695/86b7bc5797f0/fcimb-10-00095-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/032f/7080695/a27734228e81/fcimb-10-00095-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/032f/7080695/77cd5ed9ce82/fcimb-10-00095-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/032f/7080695/c5f53f0285fc/fcimb-10-00095-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/032f/7080695/86b7bc5797f0/fcimb-10-00095-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/032f/7080695/a27734228e81/fcimb-10-00095-g0004.jpg

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