Key Laboratory of Advanced Materials (MOE), Department of Chemical Engineering, Tsinghua University, Beijing, 10084, China.
Nanoscale. 2020 Apr 14;12(14):7509-7513. doi: 10.1039/d0nr00444h. Epub 2020 Mar 30.
This communication reported a hypoxia-responsive fluorescent probe based on the in situ concept, which combines a water-soluble azobenzene containing copolymer with a carbamate linkage and an anionic water-soluble aggregation-induced emission fluorogen (AIEgen) tetraphenylethene (TPE). The water-soluble copolymer can be transformed into a protonated primary amine containing polymer by the reduction of the azo bond and through a 1,6-self elimination cascade reaction under hypoxic conditions. The transition of anionic TPE from the molecular dispersed state to the aggregation state induced by self-assembly with the cationic polymer would lead to an obvious increase in fluorescence according to the AIE characteristics.
本通讯报道了一种基于原位概念的缺氧响应荧光探针，它将含有水溶性偶氮苯的共聚物与氨基甲酸酯键和阴离子水溶性聚集诱导发射荧光团（AIEgen）四苯乙烯（TPE）结合在一起。在缺氧条件下，通过还原偶氮键和通过 1,6-自身消除级联反应，水溶性共聚物可以转化为含有质子化伯胺的聚合物。根据 AIE 特性，阴离子 TPE 从分子分散状态到与阳离子聚合物自组装诱导的聚集状态的转变会导致荧光明显增强。
