State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.
J Mater Chem B. 2020 May 6;8(17):3908-3917. doi: 10.1039/d0tb00361a.
The development of new multi-functional dressing materials that effectively combine excellent antibacterial and wound healing promotion properties are highly desirable in modern biomedical research and clinical practice. In this study, a new near-infrared photo-responsive dressing material (HG1-CW) was fabricated based on a dodecyl-modified and Schiff base-linked chitosan hydrogel, a photothermal agent (WS2 nanosheets), and an antimicrobial drug (ciprofloxacin). This nanocomposite dressing possesses the advantages of being injectable, self-adapting, rapidly molding, and has good tissue adherence and excellent biocompatibility. The positive charge, macropore, and alkyl chain of the hydrogel helped to capture and restrict the bacteria. Under the irradiation of near-infrared light, the WS2 nanosheets produced a large amount of heat and simultaneously, the antibiotic was triggered to release in an on-demand fashion at the wound site, leading to the bacterial death. This synergistic therapy combining the photothermal effect and the spatially and temporally controlled drug release effectively avoided the shortcomings of each of the two individual treatment modes, and the outstanding sterilizing effect was verified by both the in vitro antibacterial tests and an S. aureus-infected mouse wound model. Furthermore, the dressing nanocomposite showed a good anti-oxidation activity, which could effectively eliminate the inflammatory responses triggered by the dead bacteria left in the infected area, avoid secondary damage to the wound tissue, and promote wound healing. This multifunctional dressing demonstrates good potential in clinical applications.
在现代生物医学研究和临床实践中，开发能够有效结合优异的抗菌和促进伤口愈合性能的新型多功能敷料材料是非常需要的。本研究基于一种十二烷基改性的席夫碱键合壳聚糖水凝胶、光热剂（WS2 纳米片）和抗菌药物（环丙沙星）制备了一种新型近红外光响应型敷料材料（HG1-CW）。这种纳米复合敷料具有可注射、自适应性、快速成型、良好的组织黏附性和优异的生物相容性等优点。水凝胶的正电荷、大孔和烷基链有助于捕获和限制细菌。在近红外光的照射下，WS2 纳米片产生大量热量，同时抗生素以按需的方式在伤口部位释放，导致细菌死亡。这种光热效应和时空控制药物释放相结合的协同治疗方法有效避免了两种单独治疗模式的缺点，体外抗菌试验和金黄色葡萄球菌感染小鼠伤口模型验证了其出色的杀菌效果。此外，该敷料纳米复合材料具有良好的抗氧化活性，可有效消除感染区域内残留死亡细菌引发的炎症反应，避免对伤口组织的二次损伤，并促进伤口愈合。这种多功能敷料在临床应用中具有良好的应用前景。
