Ding Ke, Liao Mingrui, Wang Yingyu, Lu Jian R
Biological Physics Group, Department of Physics and Astronomy, School of Natural Sciences, University of Manchester, Oxford Road, Manchester M13 9PL, UK.
Gels. 2025 May 31;11(6):420. doi: 10.3390/gels11060420.
Stimuli-responsive hydrogels have emerged as a promising class of biomaterials for advanced wound healing applications, offering dynamic and controllable responses to the wound microenvironment. These hydrogels are designed to respond to specific stimuli, such as pH, temperature, light, and enzyme activity, enabling precise regulation of drug release, antimicrobial activity, and tissue regeneration. Composite stimuli-responsive hydrogels, by integrating multiple response mechanisms and functions, show potential for addressing the diverse needs of wound healing. This review explores the biological mechanisms of wound healing, the design and classification of composite stimuli-responsive hydrogels, and the key fabrication strategies employed to optimise their properties. Despite their immense potential, unresolved challenges such as biocompatibility, long-term stability, and scalability continue to limit their translation into clinical practice. Future research will focus on integrating hydrogels with smart wearable devices, AI-driven personalised medicine, and 3D bioprinting technologies to develop next-generation wound care solutions. With continuous advancements in biomaterials science and bioengineering, stimuli-responsive hydrogels hold great promise for revolutionising wound management.
刺激响应性水凝胶已成为一类用于先进伤口愈合应用的有前途的生物材料，能够对伤口微环境做出动态且可控的响应。这些水凝胶旨在对特定刺激做出反应，如pH值、温度、光和酶活性，从而实现对药物释放、抗菌活性和组织再生的精确调控。复合刺激响应性水凝胶通过整合多种响应机制和功能，展现出满足伤口愈合多样化需求的潜力。本文综述探讨了伤口愈合的生物学机制、复合刺激响应性水凝胶的设计与分类，以及用于优化其性能的关键制备策略。尽管它们具有巨大潜力，但诸如生物相容性、长期稳定性和可扩展性等未解决的挑战仍继续限制其转化为临床实践。未来的研究将专注于将水凝胶与智能可穿戴设备、人工智能驱动的个性化医学和3D生物打印技术相结合，以开发下一代伤口护理解决方案。随着生物材料科学和生物工程的不断进步，刺激响应性水凝胶在革新伤口管理方面具有巨大潜力。
