Laboratory AGEIS EA 7407, Team Tools for e-Gnosis Medical & Labcom CNRS/UGA/OrangeLabs Telecom4Health, Faculty of Medicine, Université Grenoble Alpes, La Tronche, F-38700, France.
The National Natural History Collections, The Hebrew University of Jerusalem, Jerusalem, 91404, Israel.
Bioessays. 2020 Jun;42(6):e1900201. doi: 10.1002/bies.201900201. Epub 2020 Mar 29.
The rational design of theoretical minimal RNA rings predetermines AUG as the universal start codon. This design maximizes coded amino acid diversity over minimal sequence length, defining in silico theoretical minimal RNA rings, candidate ancestral genes. RNA rings code for 21 amino acids and a stop codon after three consecutive translation rounds, and form a degradation-delaying stem-loop hairpin. Twenty-five RNA rings match these constraints, ten start with the universal initiation codon AUG. No first codon bias exists among remaining RNA rings. RNA ring design predetermines AUG as initiation codon. This is the only explanation yet for AUG as start codon. RNA ring design determines additional RNA ring gene- and tRNA-like properties described previously, because it presumably mimics constraints on life's primordial RNAs.
理论最小 RNA 环的合理设计预先确定 AUG 为通用起始密码子。这种设计最大限度地提高了最小序列长度上编码氨基酸的多样性，定义了计算机理论最小 RNA 环，候选原始基因。RNA 环在连续三个翻译循环后编码 21 个氨基酸和一个终止密码子，并形成一个延迟降解的茎环发夹。符合这些约束条件的 RNA 环有 25 个，其中 10 个以通用起始密码子 AUG 开头。其余 RNA 环不存在第一密码子偏倚。RNA 环设计预先确定 AUG 为起始密码子。这是迄今为止对 AUG 作为起始密码子的唯一解释。RNA 环设计决定了之前描述的其他 RNA 环基因和 tRNA 样特性，因为它可能模拟了对生命原始 RNA 的限制。
