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一名患有糖尿病和肝硬化的患者发生豚鼠诺卡菌肺部感染。

Pulmonary infection with Nocardia caviae in a patient with diabetes mellitus and liver cirrhosis.

作者信息

Salh B, Fegan C, Hussain A, Jaulim A, Whale K, Webb A

机构信息

Department of Chest Diseases, Monsall Hospital, Manchester.

出版信息

Thorax. 1988 Nov;43(11):933-4. doi: 10.1136/thx.43.11.933.

DOI:10.1136/thx.43.11.933
PMID:3222767
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC461569/
Abstract

The first reported case of pulmonary infection with Nocardia caviae in Britain occurred in a 67 year old woman, in whom diabetes mellitus and liver cirrhosis probably contributed to impaired cell mediated immunity. She was successfully treated with gentamicin 60 mg eight hourly and sulphadimidine 500 mg six hourly for six months and then with sulphadimidine 2 g/day for a further three months. When Nocardia caviae is isolated from the sputum of a patient with chronic respiratory infection and fever, effective treatment should be started promptly.

摘要

英国首例关于豚鼠诺卡菌肺部感染的报告病例发生在一名67岁女性身上,糖尿病和肝硬化可能导致了其细胞介导免疫受损。她接受了为期6个月的治疗,静脉注射庆大霉素60mg,每8小时一次,口服磺胺嘧啶500mg,每6小时一次,随后又接受了为期3个月的治疗,口服磺胺嘧啶2g/天。当从慢性呼吸道感染和发热患者的痰液中分离出豚鼠诺卡菌时,应立即开始有效的治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c48/461569/fa9314b29971/thorax00275-0066-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c48/461569/fa9314b29971/thorax00275-0066-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c48/461569/fa9314b29971/thorax00275-0066-a.jpg

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本文引用的文献

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Rheumatic heart disease in scarlet-fever patients treated with penicillin; a follow-up study after seven years.用青霉素治疗的猩红热患者的风湿性心脏病;七年随访研究
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Diagnostic and therapeutic considerations in Nocardia asteroides infection.星形诺卡菌感染的诊断与治疗考量
诺卡氏菌属:宿主与寄生虫的关系。
Clin Microbiol Rev. 1994 Apr;7(2):213-64. doi: 10.1128/CMR.7.2.213.
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Enzymatic characterization of Nocardia spp. and related bacteria by API ZYM profile.通过API ZYM谱对诺卡氏菌属及相关细菌进行酶学特性分析。
Mycopathologia. 1990 Apr;110(1):51-6. doi: 10.1007/BF00442770.
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Nocardiosis of the lung: chest radiographic findings in 21 cases.肺部诺卡菌病:21例胸部X线表现
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Hypomagnesemic hypocalcemia secondary to renal magnesium wasting.继发于肾性镁消耗的低镁血症性低钙血症
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The immune response in hepatic cirrhosis: animal and human studies.肝硬化中的免疫反应:动物和人体研究
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Impaired release of parathyroid hormone in magnesium deficiency.镁缺乏时甲状旁腺激素释放受损。
J Clin Endocrinol Metab. 1976 Apr;42(4):707-17. doi: 10.1210/jcem-42-4-707.