Anast C S, Winnacker J L, Forte L R, Burns T W
J Clin Endocrinol Metab. 1976 Apr;42(4):707-17. doi: 10.1210/jcem-42-4-707.
Parathyroid hormone release and end-organ responsiveness to parathyroid extract (PTE) were evaluated in a 25-year-old woman with magnesium deficiency associated with hypocalcemia and inappropriately low levels of serum immunoreactive parathyroid hormone (iPTH). End-organ responsiveness to PTE was demonstrated by increases in serum calcium and in urinary phosphorus, cyclic AMP, and hydroxyproline. When the serum calcium was increased from a baseline of 6.9 mg/100 ml to levels of 8.0 mg/100 ml and higher by calcium infusion, the serum iPTH decreased from the low normal range to below the limits of detectability. The intravenous administration of 3 mg/kg of body weight of magnesium led to an abrupt and striking increase in circulating iPTH with a 2-fold increase in one minute, a 6-fold increase in two minutes, and an 8-fold increase in five minutes. The very rapid increase in serum iPTH produced by magnesium infusion in this study suggests an effect of magnesium on hormone secretion rather than an effect on hormone synthesis. The evidence provided by this investigation indicates that the release of parathyroid hormone is impaired in magnesium deficiency and that the level of circulating calcium required for the suppression of parathyroid hormone secretion is lower than that in normal subjects.
对一名25岁患有与低钙血症相关的镁缺乏且血清免疫反应性甲状旁腺激素（iPTH）水平异常低下的女性，评估了甲状旁腺激素释放及终末器官对甲状旁腺提取物（PTE）的反应性。通过血清钙、尿磷、环磷酸腺苷（cAMP）和羟脯氨酸的增加证明了终末器官对PTE的反应性。当通过钙输注使血清钙从6.9mg/100ml的基线水平升高至8.0mg/100ml及更高水平时，血清iPTH从低正常范围降至检测下限以下。静脉注射3mg/kg体重的镁导致循环中的iPTH急剧显著增加，1分钟内增加2倍，2分钟内增加6倍，5分钟内增加8倍。本研究中镁输注引起的血清iPTH非常快速的增加表明镁对激素分泌有影响，而非对激素合成有影响。该研究提供的证据表明，镁缺乏时甲状旁腺激素的释放受损，且抑制甲状旁腺激素分泌所需的循环钙水平低于正常受试者。
