Nolte I, Niemann C, Failing K, Müller-Berghaus G
Medizinischen und Gerichtlichen Veterinärklinik I, Justus-Liebig-Universität Giessen.
Tierarztl Prax. 1988;16(4):417-22.
The administration of 20 mg/kg of acetylsalicylic acid in 18 clinically healthy dogs resulted in a thrombocytopathy with lengthened capillary bleeding time and irreversible aggregation inhibition. Through the set up of individual dilution series, one could conclude the proportional percentage of aggregation functional transfused thrombocytes. The capillary bleeding time was shortened after the intravenous injection of prednisolone (5 mg/kg) without measurable influence on the thrombocytes. Compared to the singular use of cortisone or blood transfusion alone, the effect on capillary bleeding time became magnified when one combined transfusion and corticosteroids. The fresh blood conserves (12 hours) were, with respect to the haemostyptical properties, superior to blood stored for 5 days. The component of aggregation-functional thrombocytes was, due to the prophylactic cortisone application prior to transfusion, not increased.
对18只临床健康的犬给予20毫克/千克的乙酰水杨酸后，出现了血小板病，伴有毛细血管出血时间延长和不可逆的聚集抑制。通过建立个体稀释系列，可以得出输入的聚集功能血小板的比例百分比。静脉注射泼尼松龙（5毫克/千克）后，毛细血管出血时间缩短，且对血小板无明显影响。与单独使用可的松或输血相比，联合输血和皮质类固醇时对毛细血管出血时间的影响更大。就止血特性而言，新鲜血液保存（12小时）优于储存5天的血液。由于输血前预防性应用可的松，聚集功能血小板的成分并未增加。
