Vicerrectoría de Investigaciones, Universidad Manuela Beltrán, Bogotá, Colombia.
Facultad de Medicina, Departamento de Salud Pública, Universidad Nacional de Colombia, Bogotá, Colombia.
J Liposome Res. 2021 Jun;31(2):169-176. doi: 10.1080/08982104.2020.1749067. Epub 2020 Apr 13.
Leishmaniasis is a parasitic disease treatable and curable, however, the chemotherapeutic agents for their treatment are limited. In South American countries, pentavalent antimonials are still the first line of treatment for cutaneous leishmaniasis with an efficacy of about 75%, but the toxicity of the drug causes serious side effects and remains as the main obstacle for treatment. New knowledge aimed to improve drug delivery into the intracellular environment is essential, especially for drugs currently used in the clinic, to develop new anti- formulations. In the present study, we analysed the scientific literature to highlight the progress achieved in the last decade regarding the use of nanotechnology for improving the current leishmaniasis treatments. Results allowed us to conclude that the encapsulated Glucantime liposomal formulation can be improved by means of nanoparticle functionalization processes, resulting in new drug delivery systems that can be potentially proposed as alternative therapies for leishmaniasis treatment.
利什曼病是一种可治疗和可治愈的寄生虫病，然而，用于治疗的化学治疗药物有限。在南美国家，五价锑剂仍然是治疗皮肤利什曼病的一线药物，有效率约为 75%，但药物的毒性会导致严重的副作用，仍然是治疗的主要障碍。改善药物递送至细胞内环境的新知识至关重要，特别是对于目前在临床上使用的药物，以开发新的抗制剂。在本研究中，我们分析了科学文献，以突出在过去十年中利用纳米技术改善现有利什曼病治疗方法方面所取得的进展。研究结果表明，通过纳米颗粒功能化处理可以改善包裹葡萄糖胺脂质体的制剂，从而产生新的药物递送系统，这些系统可能被提议作为治疗利什曼病的替代疗法。
