氧化铈纳米颗粒：一种有前途的治疗纤维肉瘤的体内治疗工具。
Cerium oxide nanoparticles: A promising tool for the treatment of fibrosarcoma in-vivo.
机构信息
Department of Medical Biotechnology and Nanotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Research Center of Advanced Technology in Medicine, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.
Department of Anatomical Sciences and Cell Biology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
出版信息
Mater Sci Eng C Mater Biol Appl. 2020 Apr;109:110533. doi: 10.1016/j.msec.2019.110533. Epub 2019 Dec 6.
In this study, we used cerium oxide nanoparticles and evaluated their anti-cancer effects in a mouse model of fibrosarcoma. For evaluation of anti-cancer effects of nanoceria, tumor volume measurement, TUNEL (terminal deoxynucleotidyl transferase dUTP nick end labeling) assay, quantitative real-time PCR (qPCR) for Bax and Bcl2 genes, a panel of liver and kidney function tests and hematoxylin-eosin staining were done. Nanoceria dominantly accumulated in the tumor and it could significantly decrease tumor growth and volume in tumor-bearing mice that received nanoceria for four weeks. Cerium oxide nanoparticle showed potential anti-cancer properties against fibrosarcoma.
在这项研究中，我们使用了氧化铈纳米粒子，并在纤维肉瘤的小鼠模型中评估了它们的抗癌效果。为了评估纳米氧化铈的抗癌效果，我们进行了肿瘤体积测量、TUNEL（末端脱氧核苷酸转移酶 dUTP 缺口末端标记）检测、Bax 和 Bcl2 基因的实时定量 PCR（qPCR）检测、一系列肝肾功能检测以及苏木精-伊红染色。纳米氧化铈主要在肿瘤中积累，并且它可以显著减少接受纳米氧化铈治疗四周的荷瘤小鼠的肿瘤生长和体积。氧化铈纳米粒子对纤维肉瘤具有潜在的抗癌特性。
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