Electromagnetics for Care & Cure Laboratory (EM4C&C), Center for Care & Cure Technology Eindhoven (C3Te), Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands; Hyperthermia Unit, Department of Radiation Oncology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.
Biomedical Electromagnetics group, Department of Electrical Engineering, Chalmers University of Technology, Göteborg, Sweden.
Adv Drug Deliv Rev. 2020;163-164:3-18. doi: 10.1016/j.addr.2020.03.004. Epub 2020 Mar 27.
Hyperthermia therapy is a potent enhancer of chemotherapy and radiotherapy. In particular, microwave (MW) and radiofrequency (RF) hyperthermia devices provide a variety of heating approaches that can treat most cancers regardless the size. This review introduces the physics of MW/RF hyperthermia, the current state-of-the-art systems for both localized and regional heating, and recent advancements in hyperthermia treatment guidance using real-time computational simulations and magnetic resonance thermometry. Clinical trials involving RF/MW hyperthermia as adjuvant for chemotherapy are also presented per anatomical site. These studies favor the use of adjuvant hyperthermia since it significantly improves curative and palliative clinical outcomes. The main challenge of hyperthermia is the distribution of state-of-the-art heating systems. Nevertheless, we anticipate that recent technology advances will expand the use of hyperthermia to chemotherapy centers for enhanced drug delivery. These new technologies hold great promise not only for (image-guided) perfusion modulation and sensitization for cytotoxic drugs, but also for local delivery of various compounds using thermosensitive liposomes.
热疗是化疗和放疗的有力增强剂。特别是微波（MW）和射频（RF）热疗设备提供了多种加热方法，可以治疗大多数癌症，无论其大小如何。本文介绍了 MW/RF 热疗的物理原理、局部和区域加热的最新系统，以及使用实时计算模拟和磁共振测温进行热疗治疗指导的最新进展。还按解剖部位介绍了涉及 RF/MW 热疗作为化疗辅助治疗的临床试验。这些研究支持使用辅助热疗，因为它显著改善了治疗和姑息治疗的临床结果。热疗的主要挑战是最先进的加热系统的分布。然而，我们预计最近的技术进步将把热疗扩展到化疗中心，以增强药物输送。这些新技术不仅为（图像引导）灌注调制和细胞毒性药物的增敏带来了巨大的希望，而且还为使用热敏脂质体局部递送各种化合物带来了希望。
