Department of Pediatrics, University of Alabama at Birmingham, 1600 7(th) Avenue South, Children's Park Place North Suite G10, Birmingham, AL 35233, USA.
Department of Pediatrics, Program in Immunology, Stanford University, 269 Campus Drive, CCSR Rm 2105c, Stanford, CA 94305-5164, USA.
Clin Immunol. 2020 May;214:108396. doi: 10.1016/j.clim.2020.108396. Epub 2020 Mar 27.
Approximately 5% of children with juvenile idiopathic arthritis (JIA) are diagnosed with the psoriatic form of the disease. In recent years, there has been substantial scholarship demonstrating both heterogeneity within the disease as well as similarities with other forms of JIA, culminating in a recent proposal for the categorization of JIA that excluded the psoriatic form altogether. The purpose of the review is to summarize the clinical, epidemiologic, and genetic features of psoriatic JIA (PsJIA), comparing it with other categories of JIA including spondyloarthritis. We conclude that there are sufficient unique clinical and genetic features within PsJIA as well as similarities with its adult counterpart that warrant including it within the JIA paradigm.
约 5%的儿童青少年特发性关节炎(JIA)患者被诊断为银屑病型关节炎。近年来,大量研究表明,该疾病存在异质性,且与其他类型的 JIA 存在相似性,最终提出了一种新的 JIA 分类方法,完全排除了银屑病型关节炎。本文旨在总结银屑病型关节炎(PsJIA)的临床、流行病学和遗传学特征,并将其与包括脊柱关节炎在内的其他 JIA 类型进行比较。我们得出的结论是,PsJIA 具有足够独特的临床和遗传学特征,与成人银屑病关节炎相似,因此有理由将其纳入 JIA 范畴。