Naddei Roberta, Rebollo-Giménez Ana, Burrone Marco, Natoli Valentina, Rosina Silvia, Consolaro Alessandro, Ravelli Angelo
Dipartimento di Scienze Mediche Traslazionali, Università degli Studi di Napoli Federico II, 80131 Naples, Italy.
Clinica Pediatrica e Reumatologia, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
J Clin Med. 2023 Jan 3;12(1):367. doi: 10.3390/jcm12010367.
Juvenile psoriatic arthritis (JPsA) accounts for 1-7% of all cases of juvenile idiopathic arthritis (JIA) and its definition has been a matter of controversy among pediatric rheumatologists for many years. The traditional attribution of JPsA to the spondyloarthropathy group was challenged in the early 1990s, whereas the recent demonstrations of its heterogenous nature have led to questions about its identification as a distinct category in JIA classification. It has been shown that children with the phenotype of JPsA can be divided in two subgroups, one presenting with the features of early-onset ANA-positive JIA, and another that belongs to the spectrum of spondyloarthropathies. The few studies that have compared the clinical characteristics and genetic determinants of JPsA with those of the other JIA categories have obtained contrasting findings. The debate on the categorization of JPsA as a distinct entity within JIA classification is still ongoing and has prompted the revision of its current classification.
幼年型银屑病关节炎（JPsA）占幼年特发性关节炎（JIA）所有病例的1%-7%，多年来其定义一直是儿科风湿病学家争论的焦点。20世纪90年代初，JPsA传统上归属于脊柱关节炎组的分类受到了挑战，而最近对其异质性本质的证明引发了关于在JIA分类中将其识别为一个独立类别的质疑。研究表明，具有JPsA表型的儿童可分为两个亚组，一个表现为早发性ANA阳性JIA的特征，另一个则属于脊柱关节炎谱系。少数将JPsA与其他JIA类别进行临床特征和遗传决定因素比较的研究得出了相互矛盾的结果。关于将JPsA归类为JIA分类中一个独立实体的争论仍在继续，并促使对其当前分类进行修订。
