de Ronde Willem, Smit Diederik L
Department of Internal Medicine, Spaarne Gasthuis, Haarlem, the Netherlands.
Endocr Connect. 2020 Apr;9(4):R102-R111. doi: 10.1530/EC-19-0557.
This review summarizes 10 years experience with male abusers of anabolic androgenic steroids (AAS). The typical user of AAS is male, aged between 20 and 40 and lifting weights. Illegal AAS are cheap and easily obtained via internet or local suppliers. AAS are mostly used in cycles with a duration between 6 and 18 weeks. Most AAS cycles contain multiple agents, used simultaneously in a dose vastly exceeding a substitution dose. A variety of other performance and image-enhancing drugs are commonly used, including human growth hormone, thyroid hormone, tamoxifen, clomiphene citrate and human chorionic gonadotrophin. Short-term clinical and biochemical side effects are well established. Long-term side effects are uncertain, but may include heart failure, mood-and anxiety disorders, hypogonadism and subfertility. We share our views on the management of common health problems associated with AAS abuse.
本综述总结了10年来男性滥用合成代谢雄激素类固醇(AAS)的经验。AAS的典型使用者为20至40岁的举重男性。非法AAS价格便宜,可通过互联网或当地供应商轻松获得。AAS大多以6至18周为周期使用。大多数AAS周期包含多种药物,同时使用的剂量远远超过替代剂量。还常用各种其他提高运动表现和改善形象的药物,包括人类生长激素、甲状腺激素、他莫昔芬、枸橼酸氯米芬和人绒毛膜促性腺激素。短期临床和生化副作用已得到充分证实。长期副作用尚不确定,但可能包括心力衰竭、情绪和焦虑障碍、性腺功能减退和生育力低下。我们分享了对与AAS滥用相关的常见健康问题管理的看法。