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[士的宁对家兔感觉运动皮层神经元反应性及暂时联系的影响]

[Effect of strychnine on the neuronal reactivity of the sensorimotor cortex and the temporary connection in rabbits].

作者信息

Chizhenkova R A

出版信息

Zh Vyssh Nerv Deiat Im I P Pavlova. 1988 Sep-Oct;38(5):846-54.

PMID:3223068
Abstract

On awake nonimmobilized rabbits, evoked activity was studied of the sensorimotor cortex neurons in response to stimulation of the pyramidal tract, medial lemniscus and reticular nucleus of the midbrain tegmentum by stimuli of different frequencies, and driving reaction of cortical neurons to stimulation of these brain structures by series of stimuli of increasing frequency. Conditioned reflexes were also studied, established on the basis of combination of direct stimulation of the sensorimotor cortex and electrocutaneous stimulation. Application of the cortex of low concentration of strychnine solutions (less than 1%) heightened neurons reactivity and provides for the formation of temporary connection. Application of strychnine solutions of higher concentration (greater than 1%) led to opposite effects. Interconnection of electrical and behavioural effects is discussed.

摘要

在清醒未麻醉的家兔身上,研究了感觉运动皮层神经元对不同频率刺激锥体束、内侧丘系和中脑被盖网状核时的诱发活动,以及皮层神经元对这些脑结构以频率递增的系列刺激的驱动反应。还研究了基于感觉运动皮层直接刺激与皮肤电刺激相结合建立的条件反射。应用低浓度(小于1%)的士的宁溶液于皮层可提高神经元的反应性并促进暂时联系的形成。应用高浓度(大于1%)的士的宁溶液则产生相反的效果。文中讨论了电效应与行为效应之间的相互关系。

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