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具有不同顶角的三角形微通道中的惯性聚焦

Inertial focusing in triangular microchannels with various apex angles.

作者信息

Kim Jeong-Ah, Kommajosula Aditya, Choi Yo-Han, Lee Je-Ryung, Jeon Eun-Chae, Ganapathysubramanian Baskar, Lee Wonhee

机构信息

Department of Physics, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea.

Department of Mechanical Engineering, Iowa State University (ISU), Ames, Iowa 50011, USA.

出版信息

Biomicrofluidics. 2020 Mar 24;14(2):024105. doi: 10.1063/1.5133640. eCollection 2020 Mar.

Abstract

We consider inertial focusing of particles in channels with triangular cross sections. The number and the location of inertial focusing positions in isosceles triangular channels can change with varying blockage ratios (/) and Reynolds numbers (). In triangular channels, asymmetric velocity gradient induced by the sloped sidewalls leads to changes in the direction and the strength of the inertial lift forces. Therefore, varying the configuration (specifically, angle) of the triangular cross section is expected to lead to a better understanding of the nature of the inertial lift forces. We fabricated triangular microchannels with various apex angles using channel molds that were shaped by a planing process, which provides precise apex angles and sharp corners. The focusing position shift was found to be affected by the channel cross section, as expected. It was determined that the direction of the focusing position shift can be reversed depending on whether the vertex is acute or obtuse. More interestingly, corner focusing modes and splitting of the corner focusing were observed with increasing , which could explain the origin of the inertial focusing position changes in triangular channels. We conducted fluid dynamic simulations to create force maps under various conditions. These force maps were analyzed to identify the basins of attraction of various attractors and pinpoint focusing locations using linear stability analysis. Calculating the relative sizes of the basins of attractions and exhaustively identifying the focusing positions, which are very difficult to investigate experimentally, provided us a better understanding of trends in the focusing mechanism.

摘要

我们研究了具有三角形横截面的通道中颗粒的惯性聚焦。等腰三角形通道中惯性聚焦位置的数量和位置会随着阻塞比(/)和雷诺数()的变化而改变。在三角形通道中,倾斜侧壁引起的不对称速度梯度会导致惯性升力的方向和强度发生变化。因此,改变三角形横截面的构型(特别是角度)有望使我们更好地理解惯性升力的本质。我们使用通过刨削工艺成型的通道模具制造了具有各种顶角的三角形微通道,该工艺可提供精确的顶角和尖锐的拐角。正如预期的那样,发现聚焦位置的偏移受通道横截面的影响。已确定聚焦位置偏移的方向可根据顶点是锐角还是钝角而反转。更有趣的是,随着的增加,观察到了拐角聚焦模式和拐角聚焦的分裂,这可以解释三角形通道中惯性聚焦位置变化的起源。我们进行了流体动力学模拟,以在各种条件下创建力图。通过线性稳定性分析对这些力图进行分析,以识别各种吸引子的吸引盆并确定聚焦位置。计算吸引盆的相对大小并详尽地确定聚焦位置,这些在实验上很难研究,这使我们对聚焦机制的趋势有了更好的理解。

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本文引用的文献

1
Nonlinear Microfluidics.
Anal Chem. 2019 Jan 2;91(1):296-314. doi: 10.1021/acs.analchem.8b05042. Epub 2018 Dec 18.
2
Single stream inertial focusing in low aspect-ratio triangular microchannels.
Lab Chip. 2018 Dec 18;19(1):147-157. doi: 10.1039/c8lc00973b.
3
Microfluidics in structured multimaterial fibers.
Proc Natl Acad Sci U S A. 2018 Nov 13;115(46):E10830-E10838. doi: 10.1073/pnas.1809459115. Epub 2018 Oct 29.
4
Recent advances and current challenges in magnetophoresis based micro magnetofluidics.
Biomicrofluidics. 2018 Jun 21;12(3):031501. doi: 10.1063/1.5035388. eCollection 2018 May.
5
Recent progress of particle migration in viscoelastic fluids.
Lab Chip. 2018 Feb 13;18(4):551-567. doi: 10.1039/c7lc01076a.
6
Size-Dependent Inertial Focusing Position Shift and Particle Separations in Triangular Microchannels.
Anal Chem. 2018 Feb 6;90(3):1827-1835. doi: 10.1021/acs.analchem.7b03851. Epub 2018 Jan 10.
7
Elasto-Inertial Focusing of Mammalian Cells and Bacteria Using Low Molecular, Low Viscosity PEO Solutions.
Anal Chem. 2017 Nov 7;89(21):11653-11663. doi: 10.1021/acs.analchem.7b03093. Epub 2017 Oct 18.
8
Two-phase displacements in microchannels of triangular cross-section.
J Colloid Interface Sci. 2017 Dec 1;507:234-241. doi: 10.1016/j.jcis.2017.08.006. Epub 2017 Aug 3.
9
Long-range forces affecting equilibrium inertial focusing behavior in straight high aspect ratio microfluidic channels.
Phys Fluids (1994). 2016 Apr;28(4):043303. doi: 10.1063/1.4946829. Epub 2016 Apr 27.
10
Inertial focusing in non-rectangular cross-section microchannels and manipulation of accessible focusing positions.
Lab Chip. 2016 Mar 21;16(6):992-1001. doi: 10.1039/c5lc01100k. Epub 2016 Feb 8.

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