Chang Heng-Yu, Hwu Wuh-Liang, Chen Ching-Hui, Hou Chun-Yin, Cheng Wei
Department of Biochemistry and Molecular Cell Biology, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Department of Medical Genetics, National Taiwan University Hospital, Taipei, Taiwan.
Front Pediatr. 2020 Mar 13;8:87. doi: 10.3389/fped.2020.00087. eCollection 2020.
The use of assisted reproductive technology (ART) has increased rapidly in Taiwan. The purpose of this study is to discuss the risks of low birth weight, preterm birth, and birth defect for children conceived by assisted reproductive technology in Taiwan. Both National ART report database and National birth reports were obtained from the Health Promotion Administration in the Ministry of Health and Welfare in Taiwan. The cohort included live births ( = 1,405,625) and children conceived by ART ( = 50,988/172,818 cycles) from 2011 to 2017. The prevalence of low birth weight, preterm birth, and birth defect were compared between the ART and natural pregnancy groups. Children conceived by ART displayed a higher rate of low birth weight as compared to those in the natural pregnancy group ( < 0.001), even when analyses were restricted to singleton births ( < 0.001). A higher rate of preterm birth ( < 0.001) was also observed in children conceived by ART even when analyses were restricted to singleton births ( < 0.05). A significant increased rate of birth defects was noted from children conceived by ART < 0.05. With the increasing need for and use of ART-conceptions, the likelihood of risks induced or related to Assistant Reproductive Technology (ART) has drawn considerable attention in recent years. Taiwan, as one of the leading countries with outstanding ART performances and modern medical care, the result of the current study suggests that further consideration and tighter regulations and policy are needed with regard to the use of ART.
辅助生殖技术（ART）在台湾的使用迅速增加。本研究的目的是探讨台湾地区通过辅助生殖技术受孕的儿童出现低出生体重、早产和出生缺陷的风险。台湾地区卫生福利部国民健康署提供了ART全国报告数据库和全国出生报告。该队列包括2011年至2017年的活产儿（n = 1,405,625）以及通过ART受孕的儿童（50,988例/172,818个周期）。比较了ART组和自然受孕组低出生体重、早产和出生缺陷的发生率。与自然受孕组相比，通过ART受孕的儿童出现低出生体重的比例更高（P < 0.001），即使分析仅限于单胎分娩时也是如此（P < 0.001）。即使分析仅限于单胎分娩时（P < 0.05），通过ART受孕的儿童早产率也更高（P < 0.001）。ART受孕儿童的出生缺陷率显著增加（P < 0.05）。随着对ART受孕的需求和使用不断增加，近年来辅助生殖技术（ART）引发或与之相关的风险可能性受到了相当大的关注。台湾作为ART表现出色且医疗护理现代化的主要地区之一，本研究结果表明，在ART的使用方面需要进一步考虑并制定更严格的法规和政策。
