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富血小板血浆在治疗1型内侧上髁炎方面是手术的等效替代方法。

Platelet-Rich Plasma Is an Equal Alternative to Surgery in the Treatment of Type 1 Medial Epicondylitis.

作者信息

Bohlen Hunter L, Schwartz Zachary E, Wu Victor J, Thon Stephen G, Finley Zachary J, O'Brien Michael J, Savoie Felix H

机构信息

Department of Orthopaedics, Tulane University School of Medicine, New Orleans, Louisiana, USA.

出版信息

Orthop J Sports Med. 2020 Mar 25;8(3):2325967120908952. doi: 10.1177/2325967120908952. eCollection 2020 Mar.

Abstract

BACKGROUND

Medial epicondylitis (ME) is characterized as an overuse injury resulting in pathological alterations of the common flexor tendon at the elbow. Platelet-rich plasma (PRP) has recently become of interest in the treatment of musculoskeletal conditions as an alternative to operative management.

PURPOSE

To compare the outcomes of recalcitrant type 1 ME after treatment with either PRP or surgery.

STUDY DESIGN

Cohort study; Level of evidence, 3.

METHODS

To compare the 2 methods of treatment, we performed a retrospective review of 33 patients diagnosed with type 1 ME from 2006 to 2016 with a minimum clinical follow-up of 1 year who had failed an initial nonoperative treatment program of injections, medication, topical creams, and/or physical therapy. Overall, 15 patients were treated with a series of 2 leukocyte-rich PRP injections, and 18 patients were treated with surgery. Outcome measures included time to pain-free status, time to full range of motion (ROM), the Mayo Elbow Performance Score (MEPS), and the Oxford Elbow Score (OES). Each patient had at least 1-year follow-up. They were then contacted by telephone to determine final scores at a minimum 2-year follow-up. Unsuccessful outcomes were determined by the Nirschl grading system and failure to reach pain-free status, achieve baseline ROM, or return to previous activity.

RESULTS

The mean final follow-up was 3.9 years. A statistically significant improvement was noted in both time to full ROM (42.3 days for PRP vs 96.1 days for surgery; < .01) and time to pain-free status (56.2 days for PRP vs 108.0 days for surgery; < .01). Successful outcomes were observed in 80% of patients treated with PRP and 94% of those treated operatively ( = .37). No significant difference was found in return-to-activity rates, overall successful outcomes, MEPS scores, or OES scores.

CONCLUSION

In this case series, the use of PRP showed clinically similar outcomes to those of surgery in recalcitrant type 1 ME. PRP can be considered as an alternative to surgery in the treatment of recurrent ME, with an earlier time to full ROM and time to pain-free status compared with surgery.

摘要

背景

肱骨内上髁炎(ME)的特征是一种过度使用损伤,导致肘部常见屈肌腱发生病理改变。富血小板血浆(PRP)作为手术治疗的替代方法,最近在肌肉骨骼疾病的治疗中受到关注。

目的

比较顽固性1型ME患者接受PRP治疗或手术治疗后的疗效。

研究设计

队列研究;证据等级,3级。

方法

为比较这两种治疗方法,我们对2006年至2016年诊断为1型ME且最初接受注射、药物、外用乳膏和/或物理治疗的非手术治疗方案失败、临床随访至少1年的33例患者进行了回顾性研究。总体而言,15例患者接受了一系列2次富含白细胞的PRP注射治疗,18例患者接受了手术治疗。疗效指标包括无痛状态时间、全关节活动范围(ROM)时间、梅奥肘关节功能评分(MEPS)和牛津肘关节评分(OES)。每位患者至少随访1年。然后通过电话联系他们,以确定至少2年随访时的最终评分。不成功的结果由Nirschl分级系统确定,以及未能达到无痛状态、实现基线ROM或恢复先前活动。

结果

平均最终随访时间为3.9年。全ROM时间(PRP组为42.3天,手术组为96.1天;P <.01)和无痛状态时间(PRP组为56.2天,手术组为108.0天;P <.01)均有统计学显著改善。接受PRP治疗的患者中有80%观察到成功结果,接受手术治疗的患者中有94%观察到成功结果(P =.37)。在恢复活动率(return-to-activity rates)、总体成功结果、MEPS评分或OES评分方面未发现显著差异。

结论

在本病例系列中,PRP的使用在顽固性1型ME中显示出与手术临床相似的结果。在复发性ME的治疗中,PRP可被视为手术的替代方法,与手术相比,其全ROM时间和无痛状态时间更早。

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