Wang Genhui, Bai Fan, Tian Zan, Fan Lifang, Lei Mingjun
Department of Dermatology, Hebei Traditional Chinese Medical Hospital, Shijiazhuang City, Hebei, China.
Dermatol Ther. 2020 May;33(3):e13351. doi: 10.1111/dth.13351. Epub 2020 Apr 24.
This study aimed to evaluate whether the supplementary balneotherapy with Chinese herbal medicine (CHM) could facilitate the treatment of psoriasis vulgaris and thus be beneficial for long-term remission from the symptoms. Two hundred psoriasis vulgaris patients with moderate-to-severe plaque psoriasis from January 2013 to June 2014 were evenly divided into two groups: the consolidated therapy group (CTG) and unconsolidated therapy group (UTG); the remission period of the two groups was compared. There was no significant difference in Psoriasis Area Severity Index (PASI) score between the two groups at the beginning and the end of the treatment. However, the average remission time in CTG was 10.99 months, which was significantly longer than that of 7.94 months in UTG (P = .001). After a correction of age, course of disease, skin type as well as PASI baseline value using a COX model, we found that the risk of recurrence of psoriasis vulgaris in UTG was higher than that in the CTG (P < .001). No adverse reactions were discovered when combing the two treatments together. The combined treatment of CHM balneotherapy and narrowband ultraviolet B could significantly prolong the remission time in patients with psoriasis vulgaris.
本研究旨在评估中药药浴辅助治疗寻常型银屑病是否有助于其治疗，并从而有利于症状的长期缓解。2013年1月至2014年6月期间的200例中重度斑块状寻常型银屑病患者被平均分为两组：综合治疗组（CTG）和非综合治疗组（UTG）；比较两组的缓解期。治疗开始时和结束时，两组的银屑病面积和严重程度指数（PASI）评分无显著差异。然而，CTG的平均缓解时间为10.99个月，显著长于UTG的7.94个月（P = 0.001）。使用COX模型校正年龄、病程、皮肤类型以及PASI基线值后，我们发现UTG中寻常型银屑病复发的风险高于CTG（P < 0.001）。两种治疗联合使用时未发现不良反应。中药药浴与窄谱紫外线B联合治疗可显著延长寻常型银屑病患者的缓解时间。
