Department of Plastic Surgery, Zibo Central Hospital, Zibo, China.
Department of Plastic Surgery, Affiliated Hospital of Weifang Medical University, Weifang, China.
J Med Virol. 2020 Oct;92(10):1721-1723. doi: 10.1002/jmv.25804. Epub 2020 Apr 17.
Coronaviruses are common human viruses and include the severe acute respiratory syndrome coronavirus (SARS-CoV), the middle east respiratory syndrome coronavirus and the SARS-CoV-2. Coronaviruses mainly bind to transmembrane receptor proteins on the human cell membrane through spike proteins (S-proteins), thus releasing the RNA of the virus into the interior of the host cell to cause an infection. In this article, we discuss the mechanism and production of cyclodextrin-soluble angiotensin-converting enzyme 2 (CD-sACE2) inclusion compounds in the treatment of SARS-CoV-2 infections by blocking S-proteins. On the basis of the current research evidence, we believe that CD-sACE2 inclusion compounds have the potential to treat COVID-19. We hope that our article can provide a theoretical basis for later experiments.
冠状病毒是常见的人类病毒，包括严重急性呼吸系统综合征冠状病毒（SARS-CoV）、中东呼吸系统综合征冠状病毒和 SARS-CoV-2。冠状病毒主要通过刺突蛋白（S 蛋白）与人类细胞膜上的跨膜受体蛋白结合，从而将病毒的 RNA 释放到宿主细胞内部，引起感染。在本文中，我们讨论了通过阻断 S 蛋白治疗 SARS-CoV-2 感染的环糊精可溶性血管紧张素转换酶 2（CD-sACE2）包合物的作用机制和产生。基于目前的研究证据，我们认为 CD-sACE2 包合物具有治疗 COVID-19 的潜力。我们希望本文能为以后的实验提供理论依据。
