Turkmen Dursun
Department of Dermatology, Inonu University Faculty of Medicine, Malatya, Turkey.
J Cosmet Dermatol. 2020 Oct;19(10):2717-2720. doi: 10.1111/jocd.13395. Epub 2020 Mar 31.
Rosacea is a common chronic inflammatory skin disease that the pathogenesis is not fully understood. Although the significant role of oxidative stress in rosacea pathophysiology has been shown in recent studies, there is no study addressing the potential roles of bilirubin and uric acid (UA) in rosacea.
The purpose of this study was to assign serum bilirubin and UA antioxidant levels in rosacea patients.
Eighty-seven rosacea patients and 81 healthy controls (HCs) similar age and gender were included in the study. From all study participants, blood samples were taken and the values of total bilirubin (Tbil), direct bilirubin (Dbil), indirect bilirubin (Ibil), and UA were analyzed in the laboratory of biochemistry.
The type of rosacea was erythematotelangiectatic in 51.7% of the patients, papulopustular in 43.7%, and phymatous in 4.6%. In rosacea group serum, Tbil, Dbil, Ibil, and UA values were found to be significantly lower than in the HCs. Male rosacea patients were found to have lower Tbil, Dbil, Ibil, and UA levels when compared with the males in the HCs. There was also the same significant difference in female patients.
Main finding of our study was that when compared with the control group, serum bilirubin and UA levels were significantly lower in rosacea patients. These levels sustain the hypothesis that antioxidant status and oxidative stress are important in the pathogenesis of rosacea.
酒渣鼻是一种常见的慢性炎症性皮肤病，其发病机制尚未完全明确。尽管近期研究已表明氧化应激在酒渣鼻病理生理学中具有重要作用，但尚无研究探讨胆红素和尿酸（UA）在酒渣鼻发病机制中的潜在作用。
本研究旨在测定酒渣鼻患者血清胆红素和UA的抗氧化水平。
本研究纳入了87例酒渣鼻患者和81例年龄、性别匹配的健康对照者（HCs）。采集所有研究对象的血样，并在生物化学实验室分析总胆红素（Tbil）、直接胆红素（Dbil）、间接胆红素（Ibil）和UA的值。
51.7%的患者酒渣鼻类型为红斑毛细血管扩张型，43.7%为丘疹脓疱型，4.6%为鼻赘型。在酒渣鼻组血清中，Tbil、Dbil、Ibil和UA值均显著低于健康对照组。与健康对照组男性相比，男性酒渣鼻患者的Tbil、Dbil、Ibil和UA水平较低。女性患者也存在同样的显著差异。
我们研究的主要发现是，与对照组相比，酒渣鼻患者血清胆红素和UA水平显著降低。这些水平支持了抗氧化状态和氧化应激在酒渣鼻发病机制中起重要作用的假说。
