Edwards R D, Hansel N K, Pruessner H T, Barton B
Department of Family Practice and Community Medicine, University of Texas Health Science Center, Medical School, Houston.
J Am Board Fam Pract. 1988 Oct-Dec;1(4):245-50.
In this descriptive study of intrathecal morphine sulfate used for pain control during labor, 49 parturients received morphine intrathecally, 78 were administered butorphanol tartrate (Stadol), and 34 received no analgesia. Significant differences for the intrathecal group included: (1) decreased requirement of nitrous oxide for delivery, (2) lower number of doses of postpartum intramuscular pain medication, and (3) increased use of forceps. The intrathecal morphine group showed no prolongation of labor and no major side effects in mothers or newborns. The results suggest that the use of lower levels of intrathecal morphine sulfate (0.5 mg) is as safe and effective as the more traditional intravenous analgesia for labor.
在这项关于鞘内注射硫酸吗啡用于分娩镇痛的描述性研究中，49名产妇接受了鞘内吗啡注射，78名产妇接受了酒石酸布托啡诺（ Stadol），34名产妇未接受任何镇痛治疗。鞘内注射组的显著差异包括：（1）分娩时氧化亚氮需求减少；（2）产后肌肉注射止痛药物的剂量减少；（3）产钳使用增加。鞘内吗啡组未出现产程延长，母亲或新生儿也未出现重大副作用。结果表明，较低剂量（0.5mg）的鞘内硫酸吗啡与传统的静脉镇痛一样安全有效。
