Wu Zi Yu, Wang Su Gui, Li Qiang, Zhao Qing Song, Shao Ming Ming
Department of Urology, Huai'an Hospital Affiliated of Xuzhou Medical University, 62 South Huaihai Road, Huai'an 223002, China.
Department of Urology, Jining NO.1 People's hospital, 6 Jiankang Road, Jining 272000, China.
Math Biosci Eng. 2019 Dec 24;17(3):2037-2047. doi: 10.3934/mbe.2020108.
Prostate adenocarcinoma (PRAD) is one of the most frequently diagnosed cancer in males. Previous studies had demonstrated long non-coding RNAs (lncRNAs) played crucial roles in human cancers. In present study, we reported ten disease-free survival time related lncRNAs in PRAD, including RP11-468E2.5, GS1-393G12.13, CTD-2228K2.7, RP11-783K16.13, RP11-631N16.4, CTC-435M10.12, RP11-1109F11.5, RP11-228B15.4, RP11-496I9.1, and RP11-95O2.5. Higher expression of these lncRNAs significantly correlates to shorter DFS time in patients with PRAD. We next constructed lncRNAs regulating PPI networks in PRAD. Bioinformatics analysis revealed these DFS-related lncRNAs were associated with the regulation of cell cycle, glucose metabolic process, histone modification, and RNA splicing. AR and SPOP were identified to be involved in regulating these lncRNAs expression in PRAD. The prognostic value and molecular functions of these lnRNAs in human diseases remained largely unknown. We thought this study for the first time demonstrated that they could act as novel potential biomarkers for PRAD.
前列腺腺癌（PRAD）是男性中最常被诊断出的癌症之一。先前的研究表明，长链非编码RNA（lncRNAs）在人类癌症中起着关键作用。在本研究中，我们报告了PRAD中与无病生存时间相关的10种lncRNAs，包括RP11-468E2.5、GS1-393G12.13、CTD-2228K2.7、RP11-783K16.13、RP11-631N16.4、CTC-435M10.12、RP11-1109F11.5、RP11-228B15.4、RP11-496I9.1和RP11-95O2.5。这些lncRNAs的高表达与PRAD患者较短的无病生存期显著相关。接下来，我们构建了PRAD中lncRNAs调控的蛋白质-蛋白质相互作用（PPI）网络。生物信息学分析显示，这些与无病生存期相关的lncRNAs与细胞周期调控、葡萄糖代谢过程、组蛋白修饰和RNA剪接有关。雄激素受体（AR）和SPOP被确定参与调控PRAD中这些lncRNAs的表达。这些lncRNAs在人类疾病中的预后价值和分子功能在很大程度上仍然未知。我们认为这项研究首次证明它们可以作为PRAD新的潜在生物标志物。
