从 根的超临界流体萃取物中分离得到的两个具有抗增殖活性的新二萜。
Two new diterpenoids with their antiproliferative activities from the supercritical fluid extraction of root.
机构信息
Key Laboratory of Novel Food Resources Processing, Ministry of Agriculture and Rural Affairs/Key Laboratory of Agro-Products Processing Technology of Shandong Province/Institute of Agro-Food Science and Technology, Shandong Academy of Agricultural Sciences, Jinan, PR China.
Shandong Provincial Key Laboratory of Fruit Tree Biotechnology Breeding, Shandong Institute of Pomology, Tai'an, Shandong, China.
出版信息
Nat Prod Res. 2021 Nov;35(22):4479-4485. doi: 10.1080/14786419.2020.1731739. Epub 2020 Mar 31.
Supercritical fluid extraction was applied to obtain the lower polarity extracts from roots, and chemical investigation of which led to the isolation and identification of two new diterpenoids, named crassifolius P () and crassifolius Q (). anti-proliferative activities of compounds and on A549, Hep-G2 and Hela tumor cell lines were evaluated. The two new compounds exhibited obvious selectivity to tumor cells with IC values ranging from 20.43 ± 1.18 μM to 25.72 ± 1.32 μM.
超临界流体萃取法被应用于从根部获得低极性提取物，对其进行的化学研究导致了两种新的二萜类化合物的分离和鉴定，分别命名为 crassifolius P () 和 crassifolius Q ()。化合物 和 对 A549、Hep-G2 和 Hela 肿瘤细胞系的抗增殖活性进行了评价。这两种新化合物对肿瘤细胞表现出明显的选择性，IC 值范围为 20.43 ± 1.18 μM 至 25.72 ± 1.32 μM。
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