and anticandidal activity of (L.) sprague seeds ethanolic extract and thymol-containing hexanes fraction.

is the causative agent of candidiasis in immunocompromised and diseased individuals. The current study was designed to evaluate the antifungal activity of (L.) Sprague seeds ethanolic extract and hexanes fraction against , both and . The minimal inhibitory concentration of hexanes fraction was found to be 225 μg/mL, as compared to the standard drug amphotericin B (200 μg/mL). For the treatment of cutaneous candidiasis in BALB/c mice model, the extract and fraction containing ointment was topically applied on flank of mice at various concentrations, and 90-100% recovery in mice was observed which was better than the standard drug, clotrimazole. The GC/MS analysis of hexanes extract indicated the presence of three major components, including (43.91%), -cymene (25.53%), and γ-terpinene (22.64%). The results showed that possess potential antifungal effect, and can be used for the development of novel antifungal agents after further pre-clinical and clinical trials.